The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II comprises
multiple tandem conserved heptapeptide repeats, unique to this eukaryotic RNA …

Pre-messenger RNA (pre-mRNA) splicing is a central step in gene expression. Lying
between transcription and protein synthesis, pre-mRNA splicing removes sequences …

Transcription and splicing are functionally coupled, resulting in highly efficient splicing of
RNA polymerase II (RNAP II) transcripts. The mechanism involved in this coupling is not …

Circular RNAs (circRNAs) represent an abundant and conserved entity of non-coding RNAs;
however, the principles of biogenesis are currently not fully understood. Here, we identify …

The nucleus is highly organized, such that factors involved in the transcription and
processing of distinct classes of RNA are confined within specific nuclear bodies,. One …

Pre-mRNA splicing is frequently coupled to transcription by RNA polymerase II (RNAPII).
This coupling requires the C-terminal domain of the RNAPII largest subunit (CTD), although …

The majority of breast cancers are primarily hormone‐sensitive and can be managed by
endocrine therapy, although therapy‐resistant or hormone‐refractory cancers need …

RNA synthesis by RNA polymerase II and RNA processing are closely coupled during the
transcription cycle of protein‐coding genes. This coupling affords opportunities for quality …

RNA processing events that take place on the transcribed pre-mRNA include capping,
splicing, editing, 3′ processing, and polyadenylation. Most of these processes occur co …

To determine the role of actin–ribonucleoprotein complexes in transcription, we set out to
identify novel actin-binding proteins associated with RNA polymerase II (Pol II). Using affinity …