NONO and tumorigenesis: More than splicing

P Feng, L Li, T Deng, Y Liu, N Ling… - Journal of cellular …, 2020 - Wiley Online Library
The non‐POU domain‐containing octamer‐binding protein NONO/p54nrb, which belongs to
the Drosophila behaviour/human splicing (DBHS) family, is a multifunctional nuclear protein …

Functional coupling of RNAP II transcription to spliceosome assembly

R Das, K Dufu, B Romney, M Feldt… - Genes & …, 2006 - genesdev.cshlp.org
The pathway of gene expression in higher eukaryotes involves a highly complex network of
physical and functional interactions among the different machines involved in each step of …

PSF acts through the human immunodeficiency virus type 1 mRNA instability elements to regulate virus expression

AS Zolotukhin, D Michalowski, J Bear… - … and cellular biology, 2003 - Taylor & Francis
Human immunodeficiency virus type 1 (HIV) gag/pol and env mRNAs contain cis-acting
regulatory elements (INS) that impair stability, nucleocytoplasmic transport, and translation …

Role for PSF in mediating transcriptional activator-dependent stimulation of pre-mRNA processing in vivo

E Rosonina, JYY Ip, JA Calarco… - … and cellular biology, 2005 - Am Soc Microbiol
In a recent study, we provided evidence that strong promoter-bound transcriptional
activators result in higher levels of splicing and 3′-end cleavage of nascent pre-mRNA than …

Analysis of the interaction of influenza virus polymerase complex with human cell factors

N Jorba, S Juarez, E Torreira, P Gastaminza… - …, 2008 - Wiley Online Library
The influenza virus polymerase is formed by the PB1, PB2 and PA subunits and is required
for virus transcription and replication in the nucleus of infected cells. Here we present the …

Actin dynamics and functions in the interphase nucleus: moving toward an understanding of nuclear polymeric actin

RS Gieni, MJ Hendzel - Biochemistry and cell biology, 2009 - cdnsciencepub.com
Actin exists as a dynamic equilibrium of monomers and polymers within the nucleus of living
cells. It is utilized by the cell for many aspects of gene regulation, including mRNA …

PSF: nuclear busy‐body or nuclear facilitator?

CA Yarosh, JR Iacona, CS Lutz… - Wiley Interdisciplinary …, 2015 - Wiley Online Library
PTB‐associated splicing factor (PSF) is an abundant and essential nucleic acid‐binding
protein that participates in a wide range of gene regulatory processes and cellular response …

A coactivator trap identifies NONO (p54nrb) as a component of the cAMP-signaling pathway

AL Amelio, LJ Miraglia, JJ Conkright… - Proceedings of the …, 2007 - National Acad Sciences
Signal transduction pathways often use a transcriptional component to mediate adaptive
cellular responses. Coactivator proteins function prominently in these pathways as the …

The link between mRNA processing and transcription: communication works both ways

DAR Zorio, DL Bentley - Experimental cell research, 2004 - Elsevier
Many pre-mRNA processing events including 5′ end capping, splicing out introns, and 3′
end maturation by cleavage or polyadenylation occur while the nascent RNA chain is being …

Fox-3 and PSF interact to activate neural cell-specific alternative splicing

KK Kim, YC Kim, RS Adelstein… - Nucleic acids …, 2011 - academic.oup.com
Abstract Fox-1 family (Fox) proteins, which consist of Fox-1 (A2BP1), Fox-2 (Rbm9) and Fox-
3 (NeuN) in mammals, bind to the RNA element UGCAUG and regulate alternative pre …