The fat mass and obesity-associated protein (FTO) is the first identified demethylase of the
internal RNA modification N 6-methyladenosine (m 6 A), which also exhibits demethylation …

The influenza A virus RNA polymerase is a heterotrimeric complex responsible for viral
genome transcription and replication in the nucleus of infected cells. We recently carried out …

In Sertoli cells of testis, androgen receptor-regulated gene transcription plays an
indispensable role in maintaining spermatogenesis. Androgen receptor activity is modulated …

The tightly regulated process of precursor messenger RNA (pre-mRNA) alternative splicing
is a key mechanism to increase the number and complexity of proteins encoded by the …

Alternative splicing allows for one gene to encode multiple proteins. This mechanism is
regulated by dedicated splicing factors. However, recent data have shown that these factors …

The Alu elements are conserved~ 300 nucleotide long repeat sequences that belong to the
SINE family of retrotransposons found abundantly in primate genomes. Although the vast …

“Splicing speckles” are major nuclear domains rich in components of the splicing machinery
and polyA+ RNA. Although speckles contain little detectable transcriptional activity, they are …

Mammalian cells repair DNA double-strand breaks (DSBs) via efficient pathways of direct,
nonhomologous DNA end joining (NHEJ) and homologous recombination (HR). Prior work …

Transcription and splicing are fundamental steps in gene expression. These processes have
been studied intensively over the past four decades, and very recent findings are …

The prothrombin (F2) 3′ end formation signal is highly susceptible to thrombophilia‐
associated gain‐of‐function mutations. In its unusual architecture, the F2 3′ UTR contains …