The strong evolutionary conservation of the DNA methyltransferase, Dnmt2, is at odds with
the absence of phenotypic defects in organisms lacking Dnmt2. The cellular processes …

ABSTRACT RNA-binding proteins (RBPs) play crucial roles in the functions and
homoeostasis of various tissues by regulating multiple events of RNA processing including …

Alternative splicing is now recognized as a ubiquitous mechanism for controlling gene
expression in a tissue-specific manner. A growing body of work from the past few years has …

The progesterone receptor (PR) plays important roles in the establishment and maintenance
of pregnancy. By dynamic interactions with coregulators, PR represses the expression of …

Cells can regulate their protein repertoire in response to extracellular stimuli via alternative
splicing; however, the mechanisms controlling this process are poorly understood. The …

We have previously shown that the Epstein-Barr virus (EBV) likely encodes hundreds of viral
long noncoding RNAs (vlncRNAs) that are expressed during reactivation. Here we show that …

Gene expression is a multistep process starting in the cell nucleus with the synthesis of the
primary transcripts that undergo several modifications (including capping, splicing, and …

Background NONO-TFE3 rearranged renal cell carcinoma (NONO-TFE3 rRCC) is one of a
subtype of TFE3 rRCCs with high malignancy and poor prognosis. Compared with clear cell …

Nono is a component of the para-speckle, which stores and processes RNA. Mouse
embryonic stem cells (mESCs) lack para-speckles, leaving the function of Nono in mESCs …

The hepatitis delta virus (HDV) is an RNA virus that depends on DNA-dependent RNA
polymerase (RNAP) for its transcription and replication. While it is generally accepted that …