Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Abstract Purpose This Position Paper aims to review and discuss the available data on
therapeutic drug monitoring (TDM) of antibacterials, antifungals and antivirals in critically ill …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …

Many bacteria can infect and persist inside their hosts for long periods of time. This can be
due to immunosuppression of the host, immune evasion by the pathogen and/or ineffective …

Objective: The first 70 years of critical care can be considered a period of “industrial
revolution-like” advancement in terms of progressing the understanding and care of critical …

Background. Morbidity and mortality for critically ill patients with infections remains a global
healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in critically ill …

Early management of sepsis and septic shock is crucial for patients' prognosis. As the
Emergency Department (ED) is the place where the first medical contact for septic patients is …

Objectives To determine the existence of concentration–toxicity relationships for common β-
lactam antibiotic adverse effects and define thresholds above which toxicity is more likely …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …