Current status of PET tracers for the early diagnosis of Alzheimer's disease

Y Li, T Liu, Q Zeng, M Cui - TrAC Trends in Analytical Chemistry, 2024 - Elsevier
Positron emission tomography (PET) is a non-invasive imaging technology that can reveal
molecular alterations in the brains of Alzheimer's disease (AD) patients with high sensitivity …

PET Imaging of Innate Immune Activation Using 11C Radiotracers Targeting GPR84

M Kalita, JH Park, RC Kuo, S Hayee, S Marsango… - JACS au, 2023 - ACS Publications
Chronic innate immune activation is a key hallmark of many neurological diseases and is
known to result in the upregulation of GPR84 in myeloid cells (macrophages, microglia, and …

Aggregation-induced emission-active azines for chemosensing applications: A five-year update

AA Bhosle, M Banerjee, A Chatterjee - Sensors & Diagnostics, 2024 - pubs.rsc.org
Azines are an important class of compounds that display solvent-dependent fluorescence
emission depending upon the substituents in the aromatic scaffolds. They are affordable …

Diagnostic and Therapeutic Radiopharmaceuticals: A “Hot” Topic

CW Lindsley, CE Müller… - ACS Pharmacology & …, 2023 - ACS Publications
Translational Science, we attempted to capture some of the advances in the field of
radiolabeled pharmaceuticals for imaging and therapy. Positron emission tomography (PET) …

Coordination Chemistry of Sulfur-Containing Bifunctional Chelators: Toward in Vivo Stabilization of 64Cu PET Imaging Agents for Alzheimer's Disease

Z Yu, G Blade, BS Bouley, IT Dobrucki… - Inorganic …, 2023 - ACS Publications
The broader utilization of 64Cu positron emission tomography (PET) imaging agents has
been hindered by the unproductive demetalation induced by bioreductants. To advance the …

Screening of [18F]Florbetazine for Aβ Plaques and a Head-to-Head Comparison Study with [11C]Pittsburgh Compound-B ([11C]PiB) in Human Subjects

Y Li, X Zhang, H Zhao, Y Wang, D Zhang… - ACS Pharmacology & …, 2024 - ACS Publications
Positron emission tomography (PET) imaging of amyloid-β (Aβ) has emerged as a crucial
strategy for early diagnosis and monitoring of therapeutic advancements targeting Aβ. In our …

Development of an 18 F-labeled azobenzothiazole tracer for α-synuclein aggregates in the brain

J Wu, M Mao, J Yang, K Li, P Deng, J Zhong… - Organic & …, 2024 - pubs.rsc.org
Nuclear imaging of aggregated α-synuclein pathology is an urgent clinical need for
Parkinson's disease, yet promising tracers for brain α-synuclein aggregates are still rare. In …

Radiolabeled imaging agents for Alzheimer's disease

J Wu, K Li, J Yang, M Mao, Y Cheng - iRADIOLOGY, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder with long
preclinical and prodromal phases in older people. Molecular imaging is a promising …