Management of brain tumors is based on clinical and radiological information with
presumed grade dictating treatment. Hence, a non-invasive assessment of tumor grade is of …

Magnetic resonance spectroscopy (MRS) is a technique that combines the ability of nuclear
magnetic resonance (NMR) to differentiate molecules with the imaging features of …

Deuterium metabolic imaging (DMI) and hyperpolarized 13 C-pyruvate MRI (13 C-HPMRI)
are two emerging methods for non-invasive and non-ionizing imaging of tissue metabolism …

Hyperpolarized 13C-MRI is an emerging tool for probing tissue metabolism by measuring
13C-label exchange between intravenously injected hyperpolarized [1–13C] pyruvate and …

Aims Tumor electric fields therapy (TTFields) is emerging as a novel anti‐cancer
physiotherapy. Despite recent breakthroughs of TTFields in glioma treatment, the average …

With the development of heteronuclear fluorine, sodium, phosphorus, and other probes and
imaging technologies as well as the optimization of magnetic resonance imaging (MRI) …

In recent years, hyperpolarized 13 C magnetic resonance spectroscopic (MRS) imaging has
emerged as a complementary metabolic imaging approach. Hyperpolarization via …

The concept of the ischemic penumbra was originally defined as the area around a necrotic
stroke core and seen as the tissue at imminent risk of further damage. Today, the penumbra …

This review provides a comprehensive assessment of the development of hyperpolarized
(HP) carbon-13 metabolic MRI from the early days to the present with a focus on clinical …

Hyperpolarized MRI is emerging as a next-generation molecular imaging modality that can
detect metabolic transformations in real time deep inside tissue and organs. 13C …