Recent Advances in Domino Synthesis of Fused Polycyclic N‐Heterocycles Based on Intramolecular Alkyne Hydroamination under Copper Catalysis
Z Jin, G Shen, X Lv - Chinese Journal of Chemistry, 2023 - Wiley Online Library
Comprehensive Summary Fused polycyclic N‐heterocycles are very important scaffolds in
biomedicinal chemistry and materials science. Intramolecular alkyne hydroamination is a …
biomedicinal chemistry and materials science. Intramolecular alkyne hydroamination is a …
Natural and synthetic β-carboline as a privileged antifungal scaffolds
JK Dai, WJ Dan, JB Wan - European Journal of Medicinal Chemistry, 2022 - Elsevier
The discovery of antifungal agents with novel structure, broad-spectrum, low toxicity, and
high efficiency has been the focus of medicinal chemists. Over the past decades, β-carboline …
high efficiency has been the focus of medicinal chemists. Over the past decades, β-carboline …
New β-carboline derivatives as potential α-glucosidase inhibitor: Synthesis and biological activity evaluation
J Lin, D Xiao, L Lu, B Liang, Z Xiong, X Xu - Journal of Molecular Structure, 2023 - Elsevier
Abstract α-Glucosidase is an important therapeutic target of diabetes mellitus. To find potent
α-glucosidase inhibitors, thirty-one β-carboline derivatives containing piperazine moieties …
α-glucosidase inhibitors, thirty-one β-carboline derivatives containing piperazine moieties …
Deciphering the Mechanistic Insights of Temporary Directing-Group-Assisted meta-Alkenylation of Complex Biaryl Systems
The recently developed palladium-catalyzed C (sp2)–H olefination of 2-arylbenzaldehyde
with the aid of a temporary directing group (TDG) via reversible imine formation delivers …
with the aid of a temporary directing group (TDG) via reversible imine formation delivers …
Discovery and structural optimization of 1, 2, 3, 4-tetrahydro-β-carbolines as novel reactive oxygen species inducers for controlling intractable plant bacterial diseases
HW Liu, SS Su, SY Ma, T Li, W Fang… - Journal of Agricultural …, 2023 - ACS Publications
Nowadays, reactive oxygen species (ROS) have been acknowledged as promising
bactericidal targets against pesticide-resistant bacteria. Herein, to further excavate more …
bactericidal targets against pesticide-resistant bacteria. Herein, to further excavate more …
Tetrahydro-β-carboline derivatives as potent histone deacetylase 6 inhibitors with broad-spectrum antiproliferative activity
X Chen, J Wang, P Zhao, B Dang, T Liang… - European Journal of …, 2023 - Elsevier
A series of tetrahydro-β-carboline (THβC)-based hydroxamic acids were rationally designed
and synthesized as novel selective HDAC6 inhibitors (sHDAC6is) by the application of …
and synthesized as novel selective HDAC6 inhibitors (sHDAC6is) by the application of …
Recent developments on synthesis strategies, SAR studies and biological activities of β-Carboline derivatives–an update
The β-carboline skeleton is prevalent in a vast collection of naturally present alkaloids. Most
of these alkaloids and their derivatives have been found to show significant biological …
of these alkaloids and their derivatives have been found to show significant biological …
Engineering imine reductase for efficient biosynthesis of 1-aryl-tetrahydro-β-carbolines and their N-methylation products
J Zhu, L Yang, J Wu, Z Deng, X Qu - ACS Catalysis, 2022 - ACS Publications
Chiral 1-aryl-tetrahydro-β-carboline (THβC) is an important substructure in natural products
and pharmaceuticals. The application of imine reductase (IRED) for their enantioselective …
and pharmaceuticals. The application of imine reductase (IRED) for their enantioselective …
Synthesis and biological evaluation of 1-phenyl-tetrahydro-β-carboline-based first dual PRMT5/EGFR inhibitors as potential anticancer agents
J Zhang, X Liu, N Sa, JH Zhang, YS Cai… - European Journal of …, 2024 - Elsevier
Abstract Protein arginine methyltransferase 5 (PRMT5) and epidermal growth factor receptor
(EGFR) are both involved in the regulation of various cancer-related processes, and their …
(EGFR) are both involved in the regulation of various cancer-related processes, and their …
Re-exploration of tetrahydro-β-carboline scaffold: Discovery of selective histone deacetylase 6 inhibitors with neurite outgrowth-promoting and neuroprotective …
W Wen, J Hu, C Wang, R Yang, Y Zhang… - Bioorganic & Medicinal …, 2024 - Elsevier
Abstract Histone deacetylase 6 (HDAC6) has drawn more and more attention for its potential
application in Alzheimer's disease (AD) therapy. A series of tetrahydro-β-carboline (THβC) …
application in Alzheimer's disease (AD) therapy. A series of tetrahydro-β-carboline (THβC) …