Vertebrate photoreceptor cells can signal the absorption of a single photon and then
modulate their response as the intensity of the light and the intensity of the background …

Understanding the origin of myofibroblasts in kidney is of great interest because these cells
are responsible for scar formation in fibrotic kidney disease. Recent studies suggest …

The human genome contains large regions that are highly structured. Sequence-related
members of multigene families are often found in a clustered organization. Here we describe …

Alterations in the expression of certain genes or in their products can render benign tumor
cells metastatic. Experimentally this has been quickly performed by transferring dominantly …

The heterotrimeric CCAAT-binding factor CBF specifically interacts with the CCAAT motif
present in the proximal promoters of numerous mammalian genes. To understand the in vivo …

The FSP1 gene encodes a filament-binding S100 protein with paired EF hands that is
specifically expressed in fibroblasts. This led us to look for cis-acting elements in the FSP1 …

In the previous three reports in this series we demonstrated that the EF-hand family of
proteins evolved by a complex pattern of gene duplication, transposition, and splicing. The …

Calcium signalling occupies a preeminent position in the signal transduction system of the
cell by virtue of its participation in a wide range of physiological functions together with the …

The mts1 gene is specifically expressed in certain metastatic tumors but not in their
nonmetastatic counterparts. It is also expressed in several normal cell and tissue types that …

In the first report in this series we presented dendrograms based on 152 individual proteins
of the EF-hand family. In the second we used sequences from 228 proteins, containing 835 …