BACKGROUND & AIMS: The hereditary hemochromatosis-associated membrane proteins
HFE, TfR2, and HJV are required for adequate hepatic expression of the iron hormone …

Iron refractory iron deficiency anemia is a hereditary recessive anemia due to a defect in the
TMPRSS6 gene encoding Matriptase-2. This protein is a transmembrane serine protease …

Anemia of chronic disease (ACD) or anemia of inflammation is prevalent in patients with
chronic infection, autoimmune disease, cancer, and chronic kidney disease. ACD is …

My laboratory has been interested for some time in the influence of iron, a nutrient that is
essential for both microbial pathogens and their mammalian hosts, on the course of …

Iron is an essential nutrient that is potentially toxic due to its redox reactivity. Insufficient iron
supply to erythroid cells, the major iron consumers in the body, leads to various forms of …

Hepcidin is a central regulator of iron homeostasis. HFE and transferrin receptor 2 (TFR2)
are mutated in adult‐onset forms of hereditary hemochromatosis and regulate the …

Iron-refractory, iron-deficiency anemia (IRIDA) is a familial disorder characterized by iron
deficiency anemia unresponsive to oral iron treatment but partially responsive to intravenous …

Sažetak Iron metabolism has been intensively examined over the last decade and there are
many new players in this field which are worth to be introduced. Since its discovery many …

The bone morphogenetic protein (BMP)-SMAD signaling pathway plays a central role in
regulating hepcidin, which is the master hormone governing systemic iron homeostasis …

The liver is one of the largest and most functionally diverse organs in the human body. In
addition to roles in detoxification of xenobiotics, digestion, synthesis of important plasma …