Background Hepcidin is a major regulator of iron metabolism and plays a key role in anemia
of chronic disease, reducing intestinal iron uptake and release from body iron stores …

Anaemia or decreased blood haemoglobin is the most common blood disorder often
characterized by reduced red blood cell (RBC) numbers. RBC s are produced from …

The human body cannot actively excrete excess iron. As a consequence, iron absorption
must be strictly regulated to ensure adequate iron uptake and prevent toxic iron …

Normal iron metabolism is an inherent feature of maintaining homeostasis. There is a wide
range of iron disorders, which arise from iron deficiency or overload. In addition …

Iron has a split personality as an essential nutrient that also has the potential to generate
reactive oxygen species. We discuss how different cell types within specific tissues manage …

Hereditary hemochromatosis is a genetic disorder of iron overload. Over the past 15 years,
significant advances have been made in understanding the molecular pathogenesis of this …

Twenty years after its discovery, hepcidin is still considered the main regulator of iron
homeostasis in humans. The increase in hepcidin expression drastically blocks the flow of …

Background Disturbances in iron regulation have been described in diverse chronic liver
diseases other than hereditary haemochromatosis, and iron toxicity may worsen liver injury …

Iron availability for erythropoiesis and its dysregulation in β-thalassemia are incompletely
understood. We previously demonstrated that exogenous apotransferrin leads to more …

Abstract β‐thalassemia is a genetic disorder caused by mutations in the β‐globin gene, and
characterized by anemia, ineffective erythropoiesis and iron overload. Patients affected by …