Role of NRF2 in ovarian cancer

G Tossetta, S Fantone, E Montanari, D Marzioni… - Antioxidants, 2022 - mdpi.com
Among gynaecologic malignancies, ovarian cancer is one of the most dangerous, with a
high fatality rate and relapse due to the occurrence of chemoresistance. Many researchers …

Mitochondrial dysfunction and oxidative stress caused by cryopreservation in reproductive cells

R Gualtieri, G Kalthur, V Barbato, M Di Nardo, SK Adiga… - Antioxidants, 2021 - mdpi.com
Mitochondria, fundamental organelles in cell metabolism, and ATP synthesis are
responsible for generating reactive oxygen species (ROS), calcium homeostasis, and cell …

Melatonin drives apoptosis in head and neck cancer by increasing mitochondrial ROS generated via reverse electron transport

J Florido, L Martinez‐Ruiz… - Journal of Pineal …, 2022 - Wiley Online Library
The oncostatic effects of melatonin correlate with increased reactive oxygen species (ROS)
levels, but how melatonin induces this ROS generation is unknown. In the present study, we …

An updated review of mechanistic potentials of melatonin against cancer: pivotal roles in angiogenesis, apoptosis, autophagy, endoplasmic reticulum stress and …

S Mehrzadi, MH Pourhanifeh, A Mirzaei… - Cancer cell …, 2021 - Springer
Cancers are serious life-threatening diseases which annually are responsible for millions of
deaths across the world. Despite many developments in therapeutic approaches for affected …

Understanding the mechanism of action of melatonin, which induces ROS production in cancer cells

J Florido, C Rodriguez-Santana, L Martinez-Ruiz… - Antioxidants, 2022 - mdpi.com
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. In this context, tumor cells have an …

Melatonin mitigates cisplatin-induced ovarian dysfunction via altering steroidogenesis, inflammation, apoptosis, oxidative stress, and PTEN/PI3K/Akt/mTOR/AMPK …

A Al-Shahat, MAE Hulail, NMM Soliman, T Khamis… - Pharmaceutics, 2022 - mdpi.com
Ovarian damage and fertility impairment are major side effects of chemotherapy in pre-
menopausal cancer patients. Cisplatin is a widely used chemotherapeutic drug. The present …

Nutritional management of thyroiditis of Hashimoto

Y Danailova, T Velikova, G Nikolaev, Z Mitova… - International journal of …, 2022 - mdpi.com
Since the thyroid gland is one of the organs most affected by autoimmune processes, many
patients with thyroiditis of Hashimoto (TH) seek medical advice on lifestyle variance and …

Natural cryoprotective and cytoprotective agents in cryopreservation: A focus on melatonin

G Marcantonini, D Bartolini, L Zatini, S Costa… - Molecules, 2022 - mdpi.com
Cryoprotective and cytoprotective agents (Cytoprotective Agents) are fundamental
components of the cryopreservation process. This review presents the essentials of the …

Melatonin as an antioxidant and immunomodulator in atopic dermatitis—A new look on an old story: A Review

AK Jaworek, JC Szepietowski, P Hałubiec… - Antioxidants, 2021 - mdpi.com
Atopic dermatitis (AD) is common inflammatory dermatosis, typically with chronic and
recurrent course, which significantly reduces the quality of life. Sleep disturbances are …

The dual angiogenesis effects via Nrf2/HO-1 signaling pathway of melatonin nanocomposite scaffold on promoting diabetic bone defect repair

T Chen, Z Wu, Q Hou, Y Mei, K Yang, J Xu… - International Journal of …, 2024 - Taylor & Francis
Purpose Given the escalating prevalence of diabetes, the demand for specific bone graft
materials is increasing, owing to the greater tendency towards bone defects and more …