Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

Background Peroxisomes are single membrane-bound organelles named for their role in
hydrogen peroxide production and catabolism. However, their cellular functions extend well …

Amino acid metabolism plays important roles in tumor biology and tumor therapy.
Accumulating evidence has shown that amino acids contribute to tumorigenesis and tumor …

Dysregulation of the activity of the mechanistic target of rapamycin complex 1 (mTORC1) is
commonly linked to aging, cancer, and genetic disorders such as tuberous sclerosis (TS), a …

Ischemic stroke remains a leading cause of morbidity and disability around the world. The
sequelae of serious neurological damage are irreversible due to body's own limited repair …

Physical activity and several pharmacological approaches individually combat age-
associated conditions and extend healthy longevity in model systems. It is tantalizing to …

Background Alcohol-associated liver disease (ALD) is a major chronic liver disease around
the world without successful treatment. Acute alcoholic hepatitis is one of the most severe …

Alzheimer's disease (AD) is an age-associated neurodegenerative disease. As the
population ages, the increasing prevalence of AD threatens massive healthcare costs in the …

Dietary protein is a critical regulator of metabolic health and aging. Low protein diets are
associated with healthy aging in humans, and dietary protein restriction extends the lifespan …