Applications and challenges of CRISPR-Cas gene-editing to disease treatment in clinics

W Liu, L Li, J Jiang, M Wu, P Lin - Precision clinical medicine, 2021 - academic.oup.com
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated systems
(Cas) are efficient tools for targeting specific genes for laboratory research, agricultural …

The reservoir of latent HIV

J Chen, T Zhou, Y Zhang, S Luo, H Chen… - Frontiers in cellular …, 2022 - frontiersin.org
The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently
the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV …

Exploring nano-enabled CRISPR-Cas-powered strategies for efficient diagnostics and treatment of infectious diseases

AK Dubey, V Kumar Gupta, M Kujawska… - Journal of Nanostructure …, 2022 - Springer
Biomedical researchers have subsequently been inspired the development of new
approaches for precisely changing an organism's genomic DNA in order to investigate …

Breakthrough in CRISPR/Cas system: Current and future directions and challenges

A Ali, MM Zafar, Z Farooq, SR Ahmed… - Biotechnology …, 2023 - Wiley Online Library
Targeted genome editing (GE) technology has brought a significant revolution in fictional
genomic research and given hope to plant scientists to develop desirable varieties. This …

Why the HIV reservoir never runs dry: clonal expansion and the characteristics of HIV-infected cells challenge strategies to cure and control HIV infection

CY Lau, MA Adan, F Maldarelli - Viruses, 2021 - mdpi.com
Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target
proviral populations in cells that persist for prolonged periods and that can undergo clonal …

Latest advances of virology research using CRISPR/Cas9-based gene-editing technology and its application to vaccine development

M Teng, Y Yao, V Nair, J Luo - Viruses, 2021 - mdpi.com
In recent years, the CRISPR/Cas9-based gene-editing techniques have been well
developed and applied widely in several aspects of research in the biological sciences, in …

CRISPR/Cas9: a tool to eradicate HIV-1

R Bhowmik, B Chaubey - AIDS Research and Therapy, 2022 - Springer
The development of antiretroviral therapy (ART) has been effective in suppressing HIV
replication. However, severe drug toxicities due to the therapy and its failure in targeting the …

Antiviral therapies: advances and perspectives

BC Gonçalves, MG Lopes Barbosa… - Fundamental & …, 2021 - Wiley Online Library
Viral infections cause high morbidity and mortality, threaten public health, and impose a
socioeconomic burden. We have seen the recent emergence of SARS‐CoV‐2 (Severe …

[HTML][HTML] Toward a cure–Advancing HIV/AIDs treatment modalities beyond antiretroviral therapy: A Review

EU Alum, DE Uti, OPC Ugwu, BN Alum - Medicine, 2024 - journals.lww.com
Antiretroviral therapy, also known as antiretroviral therapy (ART), has been at the forefront of
the ongoing battle against human immunodeficiency virus/acquired immunodeficiency …

CRISPR/Cas9 ablation of integrated HIV-1 accumulates proviral DNA circles with reformed long terminal repeats

M Lai, E Maori, P Quaranta, G Matteoli, F Maggi… - Journal of …, 2021 - Am Soc Microbiol
Gene editing may be used to excise the human immunodeficiency virus type 1 (HIV-1)
provirus from the host cell genome, possibly eradicating the infection. Here, using cells …