Applications and challenges of CRISPR-Cas gene-editing to disease treatment in clinics
W Liu, L Li, J Jiang, M Wu, P Lin - Precision clinical medicine, 2021 - academic.oup.com
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated systems
(Cas) are efficient tools for targeting specific genes for laboratory research, agricultural …
(Cas) are efficient tools for targeting specific genes for laboratory research, agricultural …
The reservoir of latent HIV
J Chen, T Zhou, Y Zhang, S Luo, H Chen… - Frontiers in cellular …, 2022 - frontiersin.org
The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently
the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV …
the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV …
Exploring nano-enabled CRISPR-Cas-powered strategies for efficient diagnostics and treatment of infectious diseases
Biomedical researchers have subsequently been inspired the development of new
approaches for precisely changing an organism's genomic DNA in order to investigate …
approaches for precisely changing an organism's genomic DNA in order to investigate …
Breakthrough in CRISPR/Cas system: Current and future directions and challenges
Targeted genome editing (GE) technology has brought a significant revolution in fictional
genomic research and given hope to plant scientists to develop desirable varieties. This …
genomic research and given hope to plant scientists to develop desirable varieties. This …
Why the HIV reservoir never runs dry: clonal expansion and the characteristics of HIV-infected cells challenge strategies to cure and control HIV infection
CY Lau, MA Adan, F Maldarelli - Viruses, 2021 - mdpi.com
Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target
proviral populations in cells that persist for prolonged periods and that can undergo clonal …
proviral populations in cells that persist for prolonged periods and that can undergo clonal …
Latest advances of virology research using CRISPR/Cas9-based gene-editing technology and its application to vaccine development
M Teng, Y Yao, V Nair, J Luo - Viruses, 2021 - mdpi.com
In recent years, the CRISPR/Cas9-based gene-editing techniques have been well
developed and applied widely in several aspects of research in the biological sciences, in …
developed and applied widely in several aspects of research in the biological sciences, in …
CRISPR/Cas9: a tool to eradicate HIV-1
R Bhowmik, B Chaubey - AIDS Research and Therapy, 2022 - Springer
The development of antiretroviral therapy (ART) has been effective in suppressing HIV
replication. However, severe drug toxicities due to the therapy and its failure in targeting the …
replication. However, severe drug toxicities due to the therapy and its failure in targeting the …
Antiviral therapies: advances and perspectives
BC Gonçalves, MG Lopes Barbosa… - Fundamental & …, 2021 - Wiley Online Library
Viral infections cause high morbidity and mortality, threaten public health, and impose a
socioeconomic burden. We have seen the recent emergence of SARS‐CoV‐2 (Severe …
socioeconomic burden. We have seen the recent emergence of SARS‐CoV‐2 (Severe …
[HTML][HTML] Toward a cure–Advancing HIV/AIDs treatment modalities beyond antiretroviral therapy: A Review
Antiretroviral therapy, also known as antiretroviral therapy (ART), has been at the forefront of
the ongoing battle against human immunodeficiency virus/acquired immunodeficiency …
the ongoing battle against human immunodeficiency virus/acquired immunodeficiency …
CRISPR/Cas9 ablation of integrated HIV-1 accumulates proviral DNA circles with reformed long terminal repeats
Gene editing may be used to excise the human immunodeficiency virus type 1 (HIV-1)
provirus from the host cell genome, possibly eradicating the infection. Here, using cells …
provirus from the host cell genome, possibly eradicating the infection. Here, using cells …