Eukaryotic genomes are pervasively transcribed. Besides protein-coding RNAs, there are
different types of non-coding RNAs that modulate complex molecular and cellular …

Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …

Chromosomes are the physical realization of genetic information and thus form the basis for
its readout and propagation. Here we present a high-resolution chromosomal contact map …

The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a bona fide long
noncoding RNA (lncRNA). MALAT1, also known as nuclear-enriched transcript 2 (NEAT2) …

Mammalian genomes are populated with thousands of transcriptional enhancers that
orchestrate cell-type-specific gene expression programs,,,, but how those enhancers are …

Nuclear bodies including nucleoli, Cajal bodies, nuclear speckles, Polycomb bodies, and
paraspeckles are membraneless subnuclear organelles. They are present at steady-state …

Although eukaryotic nuclei contain distinct architectural structures associated with
noncoding RNAs (ncRNAs), their potential relationship to regulated transcriptional programs …

The safety of progestogens as a class has come under increased scrutiny after the
publication of data from the Women's Health Initiative trial, particularly with respect to breast …

While global chromatin conformation studies are emerging, very little is known about the
chromatin conformation of human telomeres. Most studies have focused on the role of …

The discovery of interchromosomal interactions in higher eukaryotes points to a functional
interplay between genome architecture and gene expression, challenging the view of …