The Brugada syndrome is an inherited disorder associated with risk of ventricular fibrillation
and sudden cardiac death in a structurally normal heart. Diagnosis is based on a …

Sudden cardiac death (SCD) and arrhythmia represent a major worldwide public health
problem, accounting for 15–20% of all deaths. Early resuscitation and defibrillation remains …

Sudden cardiac death poses a unique challenge to clinicians because it may be the only
symptom of an inherited heart condition. Indeed, inherited heart diseases can cause sudden …

Background: Heart conditions impose physical, social, financial and health-related quality of
life limitations on individuals in Brazil. Objectives: This study assessed the economic burden …

Brugada syndrome is a rare, inherited cardiac disease leading to ventricular fibrillation and
sudden cardiac death in structurally normal hearts. Clinical diagnosis requires a Brugada …

Calcium ions are the major signaling ions in the cells. They regulate muscle contraction,
neurotransmitter secretion, cell growth and migration, and the activity of several proteins …

The diffusion of next-generation sequencing (NGS)-based approaches allows for the
identification of pathogenic mutations of cardiomyopathies and channelopathies in more …

Cardiovascular diseases (CVD) are one of the leading causes of morbidity and mortality
worldwide. mtDNA (mitochondrial DNA) mutations are known to participate in the …

Technical advances in generating and phenotyping cardiomyocytes from human pluripotent
stem cells (hPSC-CMs) are now driving their wider acceptance as in vitro models to …

In many SCD cases, in particular in pediatric age, autopsy can be completely negative and
then a post-mortem genetic testing (molecular autopsy) is indicated. In NGS era finding …