Basic concepts and potential applications of genetics and genomics for cardiovascular and stroke clinicians: a scientific statement from the American Heart …

K Musunuru, KT Hickey, SM Al-Khatib… - Circulation …, 2015 - Am Heart Assoc
The American Heart Association makes every effort to avoid any actual or potential conflicts
of interest that may arise as a result of an outside relationship or a personal, professional, or …

[HTML][HTML] The multi-faceted aspects of the complex cardiac Nav1. 5 protein in membrane function and pathophysiology

N Detta, G Frisso, F Salvatore - … et Biophysica Acta (BBA)-Proteins and …, 2015 - Elsevier
The aim of this mini-review is to draw together the main concepts and findings that have
emerged from recent studies of the cardiac channel protein Na v 1.5. This complex protein is …

Genetics of channelopathies associated with sudden cardiac death

O Campuzano, G Sarquella-Brugada… - … Science and Practice, 2015 - qscience.com
Recent technological advances in cardiology have resulted in new guidelines for the
diagnosis, treatment and prevention of diseases. Despite these improvements, sudden …

Characterization of SEMA3A-Encoded Semaphorin as a Naturally Occurring Kv4.3 Protein Inhibitor and its Contribution to Brugada Syndrome

NJ Boczek, D Ye, EK Johnson, W Wang… - Circulation …, 2014 - Am Heart Assoc
Rationale: Semaphorin 3A (SEMA3A)-encoded semaphorin is a chemorepellent that
disrupts neural patterning in the nervous and cardiac systems. In addition, SEMA3A has an …

iPSC-cardiomyocyte models of Brugada syndrome—achievements, challenges and future perspectives

A Nijak, J Saenen, AJ Labro, D Schepers… - International journal of …, 2021 - mdpi.com
Brugada syndrome (BrS) is an inherited cardiac arrhythmia that predisposes to ventricular
fibrillation and sudden cardiac death. It originates from oligogenic alterations that affect …

The role of semaphorins in cardiovascular diseases: Potential therapeutic targets and novel biomarkers.

Z Yin, J Zhang, S Xu, J Liu, Y Xu, J Yu… - … : Official Publication of …, 2022 - europepmc.org
Semaphorins (Semas), which belongs to the axonal guidance molecules, include 8 classes
and could affect axon growth in the nervous system. Recently, semaphorins were found to …

Broad electrocardiogram syndromes spectrum: from common emergencies to particular electrical heart disorders

A Balta, A Ceasovschih, V Șorodoc… - Journal of Personalized …, 2022 - mdpi.com
Electrocardiogram (ECG) still remains a very useful diagnostic method in modern
cardiology. Its broad availability, noninvasiveness and good sensitivity explain why it plays a …

Mutation in S6 domain of HCN4 channel in patient with suspected Brugada syndrome modifies channel function

S Biel, M Aquila, B Hertel, A Berthold… - … -European Journal of …, 2016 - Springer
Diseases such as the sick sinus and the Brugada syndrome are cardiac abnormalities,
which can be caused by a number of genetic aberrances. Among them are mutations in …

[HTML][HTML] Attendance-related healthcare resource utilisation and costs in patients with Brugada syndrome in Hong Kong: a retrospective cohort study

S Lee, CT Chung, OHI Chou, TTL Lee… - Current problems in …, 2023 - Elsevier
Understanding health care resource utilisation and its associated costs are important for
identifying areas of improvement regarding resource allocations. However, there is limited …

Sudden cardiac death—a new insight into potentially fatal genetic markers

D Primorac, L Odak, V Perić, J Ćatić, J Šikić… - Frontiers in …, 2021 - frontiersin.org
Sudden cardiac death (SCD) is an unexpected and dramatic event. It draws special attention
especially in young, seemingly healthy athletes. Our scientific paper is based on the death of …