Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen that causes a range
of serious infections that are often challenging to treat, as this pathogen can express multiple …

Pneumonia is frequently encountered in clinical practice, and Gram-negative bacilli
constitute a significant proportion of its aetiology, especially when it is acquired in a hospital …

Background A growing body of observational evidence supports the value of ceftazidime-
avibactam (CAZ-AVI) in managing infections caused by carbapenem-resistant …

Carbapenem-resistant Enterobacterales (CRE) and Pseudomonas aeruginosa (CR-PA)
producing metallo-β-lactamases (MBLs) cause severe nosocomial infections with no defined …

Background Healthcare-associated infections involving Gram-negative bacteria (GNB) with
difficult-to-treat resistance (DTR) phenotype are associated with impaired patient-centered …

Bacterial resistance mechanisms are continuously and rapidly evolving. This is particularly
true for Gram-negative bacteria. Over the last decade, the strategy to develop new β …

A comprehensive review of drug penetration into pulmonary epithelial lining fluid (ELF) was
previously published in 2011. Since then, an extensive number of studies comparing plasma …

The challenging severity of some infections, especially in critically ill patients, makes the
diffusion of antimicrobial drugs within tissues one of the cornerstones of chemotherapy. The …

Ventilator-associated pneumonia (VAP) in critically ill patients with COVID-19 represents a
very huge global threat due to a higher incidence rate compared to non-COVID-19 patients …

Objectives Based on recent pharmacokinetic/pharmacodynamic (PK/PD) evidence,
continuous-infusion (CI) β-lactam administration is increasingly recommended for serious …