General anaesthesia is usually considered to safely induce a reversible brain state allowing
the performance of surgery under optimal conditions. An increasing number of clinical and …

General anesthesia has been unequivocally linked to abnormal development of the central
nervous system, leading to neurocognitive impairments in laboratory models. In vitro and in …

Importance Exposure of young animals to commonly used anesthetics causes neurotoxicity
including impaired neurocognitive function and abnormal behavior. The potential …

Background Preclinical data suggest that general anaesthetics affect brain development.
There is mixed evidence from cohort studies that young children exposed to anaesthesia …

BACKGROUND: Annually, millions of children are exposed to anesthetic agents that cause
apoptotic neurodegeneration in immature animals. To explore the possible significance of …

BACKGROUND: Over the past decade, the safety of anesthetic agents in children has been
questioned after the discovery that immature animals exposed to anesthesia display …

The Netherlands Twin Register (NTR) is a national register in which twins, multiples and
their parents, siblings, spouses and other family members participate. Here we describe the …

Importance The results of preclinical studies suggest that anesthetic drugs administered to
neonatal animals cause widespread neuronal apoptosis and later neurocognitive …

Background Exposure of young animals to general anesthesia causes neurodegeneration
and lasting behavioral abnormalities; whether these findings translate to children remains …

BACKGROUND: In vitro and in vivo studies of anesthetics have demonstrated serious
neurotoxic effects on the developing brain. However, the clinical relevance of these findings …