The fidelity of splice site selection is thought to be critical for proper gene expression and
cellular fitness. In particular, proper recognition of 3′-splice site (3′ SS) sequences by the …

Cycling of cells requires duplication of the genetic information which is encoded in the DNA.
During the S-phase of the cell cycle, when DNA replication occurs, cells have to tolerate …

Splicing of pre-mRNA is initiated by binding of U1 snRNP to the 5'splice site and of Msl5-
Mud2 heterodimer to the branch site (BS), together forming the commitment complex (CC) …

Transcription is a fundamental process catalyzed by DNA-dependent RNA polymerases
(DdRPs). Interestingly, some DdRPs can use both DNA and RNA as templates for …

Регуляция альтернативного сплайсинга в клетках эукариот осуществляется за счет
скоординированного действия большого числа факторов, включающих в РНК …

Transcription is a fundamental process catalyzed by DNA-dependent RNA polymerases
(DdRPs). Interestingly, some DdRPs can use both DNA and RNA as templates for …

Thèse présentée à la Faculté de médecine et des sciences de la santé en vue de l'obtention
du diplôme de philosophiae doctor (Ph. D.) en microbiologie, Faculté de médecine et des …

In yeast, most ribosomal proteins are produced from duplicated genes. These nearly
identical protein pairs are expressed at varying levels, with one 'major paralog'usually …

The regulation of gene expression and RNA maturation underlies fundamental processes
such as cell homeostasis, development, and stress acclimation. The biogenesis and …

To characterize the rules governing exon recognition during splicing, we analysed dozens of
RNA-seq datasets and identified~ 3,200 GC-rich exons and~ 4,000 AT-rich exons whose …