Pharmacokinetic considerations for drugs that treat diarrhea-predominant irritable bowel syndrome: what's new?
Introduction Irritable bowel syndrome (IBS), which presents a significant healthcare and
socioeconomic burden, is one of the main issues in the field of therapy. Hence, it is …
socioeconomic burden, is one of the main issues in the field of therapy. Hence, it is …
Regulation of PXR in drug metabolism: chemical and structural perspectives
ABSTRACT Introduction Pregnane X receptor (PXR) is a master xenobiotic sensor that
transcriptionally controls drug metabolism and disposition pathways. PXR activation by …
transcriptionally controls drug metabolism and disposition pathways. PXR activation by …
In vitro safety signals for potential clinical development of the anti-inflammatory pregnane X receptor agonist FKK6
Z Dvořák, B Vyhlídalová, P Pečinková, H Li… - Bioorganic …, 2024 - Elsevier
Based on the mimicry of microbial metabolites, functionalized indoles were demonstrated as
the ligands and agonists of the pregnane X receptor (PXR). The lead indole, FKK6 …
the ligands and agonists of the pregnane X receptor (PXR). The lead indole, FKK6 …