FANCM is a multifunctional DNA repair enzyme that acts as a sensor and coordinator of
replication stress responses, especially interstrand crosslink (ICL) repair mediated by the …

DNA interstrand cross-links (ICLs) represent a major barrier blocking DNA replication fork
progression. ICL accumulation results in growth arrest and cell death—particularly in cell …

Non-obstructive azoospermia (NOA) is the most severe disease in male infertility, but the
genetic causes for the majority of NOA remain unknown. FANCM is a member of Fanconi …

Breast cancer is a common disease partially caused by genetic risk factors. Germline
pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are …

Fanconi anemia is a rare recessive disease characterized by multiple congenital
abnormalities, progressive bone marrow failure, and a predisposition to malignancies. It …

FANCM is named after Fanconi anemia (FA) complement group M. The clinical symptoms of
FA include congenital abnormalities, pancytopenia, and cancer proneness. However, recent …

Bone marrow failure (BMF) related to hypoplasia of hematopoietic elements in the bone
marrow is a heterogeneous clinical entity with a broad differential diagnosis including both …

The human FANCM ATPase/translocase is involved in various cellular pathways including
DNA damage repair, replication fork remodeling and R-loop resolution. Recently, reports …

The development of breast cancer depends on several risk factors, including environmental,
lifestyle and genetic factors. Despite the evolution of DNA sequencing techniques and …

Leukaemia is caused by the clonal evolution of a cell that accumulates mutations/genomic
rearrangements, allowing unrestrained cell growth. However, recent identification of …