The advance in our understanding of the biogenesis of various endogenous opioid
peptides, their anatomical distribution, and the characteristics of the multiple receptors with …

Despite the recent introduction of a number of new compounds, there has of late been a
cooling of interest by pharmaceutical companies in the development of centrally-active …

Erfahren Sie alles über Opioide, was Sie schon immer wissen wollten:-Physiologie des
Schmerzgeschehens,-Wirkungsweise, Nebenwirkungen von Opioiden,-Indikationen und …

Studies in both animal and clinical models suggest that opioids exert their analgesic effects
not only through activation of receptors in the CNS but also through interaction with …

Irritable bowel syndrome (IBS) is a multifactorial condition with principal symptoms of pain
and altered bowel function. The kappa-opioid agonist asimadoline is being evaluated in …

Publisher Summary This chapter discusses the possible involvement of opioids in mediating
physiological as well as psychological reactions to stress. It focuses on the neurobiological …

Sind Opioide noch immer die wirkungsstärksten Analgetika im Armentarium eines
Therapeuten, so stellen jedoch Unsicherheiten in der Wahl des Produktes, der Dosierung …

It has recently been demonstrated that selective inhibition of both neuronal constitutive and
inducible nitric oxide synthases (ncNOS and iNOS) is neuroprotective in a model of …

Background Considering the extensive innervation of the pulp tissue, asymptomatic
irreversible pulpitis (AIP) or “silent pulpitis” represents a confounding clinical condition …

Um an den spezifischen Opioidrezeptor im ZNS zu gelangen, muss das Opioid nach einer
intravenösen, intramuskulären oder subkutanen Injektion die Blut-Hirn-Schranke …