Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …

Cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain,
which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc. At present, there …

Abstract Nrf2 (NFE2L2–nuclear factor (erythroid-derived 2)-like 2) is a transcription factor,
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

Abstract The Nrf2-Keap1-ARE pathway is a redox and xenobiotic sensitive signaling axis
that functions to protect cells against oxidative stress, environmental toxicants, and harmful …

Environmental and occupational exposure to cadmium has been shown to induce kidney
damage, liver injury, neurodegenerative disease, and osteoporosis. However, the …

Mounting evidence suggests that autophagy is a more selective process than originally
anticipated. The discovery and characterization of autophagic adapters, like p62 and NBR1 …

Inflammation and oxidative stress are thought to promote tissue damage in multiple
sclerosis. Thus, novel therapeutics enhancing cellular resistance to free radicals could prove …

The p62/SQSTM1 (sequestosome 1) protein, which acts as a cargo receptor for autophagic
degradation of ubiquitinated targets, is up-regulated by various stressors. Induction of the …

The classical genetic approach for exploring biological pathways typically begins by
identifying mutations that cause a phenotype of interest. Overexpression or misexpression of …