Pharmacological aspects and biological effects of cannabigerol and its synthetic derivatives
F Calapai, L Cardia, E Esposito… - Evidence‐Based …, 2022 - Wiley Online Library
Cannabigerol (CBG) is a cannabinoid from the plant Cannabis sativa that lacks
psychotomimetic effects. Its precursor is the acidic form, cannabigerolic acid (CBGA), which …
psychotomimetic effects. Its precursor is the acidic form, cannabigerolic acid (CBGA), which …
NLR-dependent regulation of inflammation in multiple sclerosis
M Gharagozloo, KV Gris, T Mahvelati… - Frontiers in …, 2018 - frontiersin.org
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
associated with inappropriate activation of lymphocytes, hyperinflammatory responses …
associated with inappropriate activation of lymphocytes, hyperinflammatory responses …
Human induced pluripotent stem cell-derived astrocytes are differentially activated by multiple sclerosis-associated cytokines
S Perriot, A Mathias, G Perriard, M Canales… - Stem cell reports, 2018 - cell.com
Recent studies highlighted the importance of astrocytes in neuroinflammatory diseases,
interacting closely with other CNS cells but also with the immune system. However, due to …
interacting closely with other CNS cells but also with the immune system. However, due to …
Age-associated resident memory CD8 T cells in the central nervous system are primed to potentiate inflammation after ischemic brain injury
Aging is associated with an increase in basal inflammation in the CNS and an overall
decline in cognitive function and poorer recovery following injury. Growing evidence …
decline in cognitive function and poorer recovery following injury. Growing evidence …
Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models
Background α-Synuclein (α-syn) is a pre-synaptic protein which progressively accumulates
in neuronal and non-neuronal cells in neurodegenerative diseases such as Parkinson's …
in neuronal and non-neuronal cells in neurodegenerative diseases such as Parkinson's …
Expanding role of T cells in human autoimmune diseases of the central nervous system
It is being increasingly recognized that a dysregulation of the immune system plays a vital
role in neurological disorders and shapes the treatment of the disease. Aberrant T cell …
role in neurological disorders and shapes the treatment of the disease. Aberrant T cell …
Astrocytes and inflammatory T helper cells: a dangerous liaison in multiple sclerosis
M Kunkl, C Amormino, V Tedeschi, MT Fiorillo… - Frontiers in …, 2022 - frontiersin.org
Multiple Sclerosis (MS) is a neurodegenerative autoimmune disorder of the central nervous
system (CNS) characterized by the recruitment of self-reactive T lymphocytes, mainly …
system (CNS) characterized by the recruitment of self-reactive T lymphocytes, mainly …
T cells actively infiltrate the white matter of the aging monkey brain in relation to increased microglial reactivity and cognitive decline
KV Batterman, PE Cabrera, TL Moore… - Frontiers in …, 2021 - frontiersin.org
Normal aging is characterized by declines in processing speed, learning, memory, and
executive function even in the absence of neurodegenerative diseases such as Alzheimer's …
executive function even in the absence of neurodegenerative diseases such as Alzheimer's …
The regulatory role of NLRX1 in innate immunity and human disease
M Liu, K Liu, D Cheng, B Zheng, S Li, Z Mo - Cytokine, 2022 - Elsevier
Nucleotide binding and oligomerization domain (NOD)-like receptor (NLR) initially appeared
in the public view as a cytoplasmic pathogen recognition receptor (PRR) that plays an …
in the public view as a cytoplasmic pathogen recognition receptor (PRR) that plays an …
Tissue regulatory T cells and neural repair
M Ito, K Komai, T Nakamura, T Srirat… - International …, 2019 - academic.oup.com
Inflammation and immune responses after tissue injury play pivotal roles in the pathology,
resolution of inflammation, tissue recovery, fibrosis and remodeling. Regulatory T cells …
resolution of inflammation, tissue recovery, fibrosis and remodeling. Regulatory T cells …