Pharmacological aspects and biological effects of cannabigerol and its synthetic derivatives

F Calapai, L Cardia, E Esposito… - Evidence‐Based …, 2022 - Wiley Online Library
Cannabigerol (CBG) is a cannabinoid from the plant Cannabis sativa that lacks
psychotomimetic effects. Its precursor is the acidic form, cannabigerolic acid (CBGA), which …

NLR-dependent regulation of inflammation in multiple sclerosis

M Gharagozloo, KV Gris, T Mahvelati… - Frontiers in …, 2018 - frontiersin.org
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
associated with inappropriate activation of lymphocytes, hyperinflammatory responses …

Human induced pluripotent stem cell-derived astrocytes are differentially activated by multiple sclerosis-associated cytokines

S Perriot, A Mathias, G Perriard, M Canales… - Stem cell reports, 2018 - cell.com
Recent studies highlighted the importance of astrocytes in neuroinflammatory diseases,
interacting closely with other CNS cells but also with the immune system. However, due to …

Age-associated resident memory CD8 T cells in the central nervous system are primed to potentiate inflammation after ischemic brain injury

RM Ritzel, J Crapser, AR Patel, R Verma… - The Journal of …, 2016 - journals.aai.org
Aging is associated with an increase in basal inflammation in the CNS and an overall
decline in cognitive function and poorer recovery following injury. Growing evidence …

Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models

M Iba, C Kim, M Sallin, S Kwon, A Verma… - Journal of …, 2020 - Springer
Background α-Synuclein (α-syn) is a pre-synaptic protein which progressively accumulates
in neuronal and non-neuronal cells in neurodegenerative diseases such as Parkinson's …

Expanding role of T cells in human autoimmune diseases of the central nervous system

D Pilli, A Zou, F Tea, RC Dale, F Brilot - Frontiers in immunology, 2017 - frontiersin.org
It is being increasingly recognized that a dysregulation of the immune system plays a vital
role in neurological disorders and shapes the treatment of the disease. Aberrant T cell …

Astrocytes and inflammatory T helper cells: a dangerous liaison in multiple sclerosis

M Kunkl, C Amormino, V Tedeschi, MT Fiorillo… - Frontiers in …, 2022 - frontiersin.org
Multiple Sclerosis (MS) is a neurodegenerative autoimmune disorder of the central nervous
system (CNS) characterized by the recruitment of self-reactive T lymphocytes, mainly …

T cells actively infiltrate the white matter of the aging monkey brain in relation to increased microglial reactivity and cognitive decline

KV Batterman, PE Cabrera, TL Moore… - Frontiers in …, 2021 - frontiersin.org
Normal aging is characterized by declines in processing speed, learning, memory, and
executive function even in the absence of neurodegenerative diseases such as Alzheimer's …

The regulatory role of NLRX1 in innate immunity and human disease

M Liu, K Liu, D Cheng, B Zheng, S Li, Z Mo - Cytokine, 2022 - Elsevier
Nucleotide binding and oligomerization domain (NOD)-like receptor (NLR) initially appeared
in the public view as a cytoplasmic pathogen recognition receptor (PRR) that plays an …

Tissue regulatory T cells and neural repair

M Ito, K Komai, T Nakamura, T Srirat… - International …, 2019 - academic.oup.com
Inflammation and immune responses after tissue injury play pivotal roles in the pathology,
resolution of inflammation, tissue recovery, fibrosis and remodeling. Regulatory T cells …