Exosomes as mediators of intercellular crosstalk in metabolism

R Isaac, FCG Reis, W Ying, JM Olefsky - Cell metabolism, 2021 - cell.com
Exosomes are nanoparticles secreted by all cell types and are a large component of the
broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted …

Extracellular vesicles and particles impact the systemic landscape of cancer

S Lucotti, CM Kenific, H Zhang, D Lyden - The EMBO journal, 2022 - embopress.org
Intercellular cross talk between cancer cells and stromal and immune cells is essential for
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …

Insight into extracellular vesicle-cell communication: from cell recognition to intracellular fate

L Ginini, S Billan, E Fridman, Z Gil - Cells, 2022 - mdpi.com
Extracellular vesicles (EVs) are heterogamous lipid bilayer-enclosed membranous
structures secreted by cells. They are comprised of apoptotic bodies, microvesicles, and …

Re-engineering extracellular vesicles as smart nanoscale therapeutics

JPK Armstrong, MN Holme, MM Stevens - ACS nano, 2017 - ACS Publications
In the past decade, extracellular vesicles (EVs) have emerged as a key cell-free strategy for
the treatment of a range of pathologies, including cancer, myocardial infarction, and …

Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1‐targeting miRNA‐92a‐1‐5p

L Yu, B Sui, W Fan, L Lei, L Zhou… - Journal of …, 2021 - Wiley Online Library
In patients with prostate cancer (PCa), bone lesions appear osteoblastic in radiographs;
however, pathological fractures frequently occur in PCa patients, and bone resorption is …

Extracellular vesicles: potential roles in regenerative medicine

OG De Jong, BWM Van Balkom… - Frontiers in …, 2014 - frontiersin.org
Extracellular vesicles (EV) consist of exosomes, which are released upon fusion of the
multivesicular body with the cell membrane, and microvesicles, which are released directly …

Mass-spectrometry-based molecular characterization of extracellular vesicles: lipidomics and proteomics

S Kreimer, AM Belov, I Ghiran, SK Murthy… - Journal of proteome …, 2015 - ACS Publications
This review discusses extracellular vesicles (EVs), which are submicron-scale, anuclear,
phospholipid bilayer membrane enclosed vesicles that contain lipids, metabolites, proteins …

Exosome: a novel approach to stimulate bone regeneration through regulation of osteogenesis and angiogenesis

Y Qin, R Sun, C Wu, L Wang, C Zhang - International journal of molecular …, 2016 - mdpi.com
The clinical need for effective bone regeneration therapy remains in huge demands.
However, the current “gold standard” treatments of autologous and allogeneic bone grafts …

The roles of bone‐derived exosomes and exosomal micro RNA s in regulating bone remodelling

Y Xie, Y Chen, L Zhang, W Ge… - Journal of cellular and …, 2017 - Wiley Online Library
Pathological destructive bone diseases are primarily caused by the failure of a lifelong self‐
renewal process of the skeletal system called bone remodelling. The mechanisms …

Systematic review of targeted extracellular vesicles for drug delivery–considerations on methodological and biological heterogeneity

JM Gudbergsson, K Jønsson, JB Simonsen… - Journal of Controlled …, 2019 - Elsevier
The idea of using extracellular vesicles (EVs) for targeted drug delivery was first introduced
in 2011 and has since then gained increasing attention as promising new candidates in the …