Natural products in licorice for the therapy of liver diseases: Progress and future opportunities

X Li, R Sun, R Liu - Pharmacological Research, 2019 - Elsevier
Liver diseases related complications represent a significant source of morbidity and mortality
worldwide, creating a substantial economic burden. Oxidative stress, excessive …

Dissecting the crosstalk between Nrf2 and NF-κB response pathways in drug-induced toxicity

W Gao, L Guo, Y Yang, Y Wang, S Xia… - Frontiers in cell and …, 2022 - frontiersin.org
Nrf2 and NF-κB are important regulators of the response to oxidative stress and
inflammation in the body. Previous pharmacological and genetic studies have confirmed …

Galangin activates Nrf2 signaling and attenuates oxidative damage, inflammation, and apoptosis in a rat model of cyclophosphamide-induced hepatotoxicity

SH Aladaileh, MH Abukhalil, SAM Saghir, H Hanieh… - Biomolecules, 2019 - mdpi.com
Cyclophosphamide (CP) is a widely used chemotherapeutic agent; however, its clinical
application is limited because of its multi-organ toxicity. Galangin (Gal) is a bioactive …

Activation of Nrf2/HO-1 pathway by nardochinoid C inhibits inflammation and oxidative stress in lipopolysaccharide-stimulated macrophages

JF Luo, XY Shen, CK Lio, Y Dai, CS Cheng… - Frontiers in …, 2018 - frontiersin.org
The roots and rhizomes of Nardostachys chinensis have neuroprotection and cardiovascular
protection effects. However, the specific mechanism of N. chinensis is not yet clear …

Protective effects of licochalcone A ameliorates obesity and non-alcoholic fatty liver disease via promotion of the Sirt-1/AMPK pathway in mice fed a high-fat diet

CJ Liou, YK Lee, NC Ting, YL Chen, SC Shen, SJ Wu… - Cells, 2019 - mdpi.com
Licochalcone A is a chalcone isolated from Glycyrrhiza uralensis. It showed anti-tumor and
anti-inflammatory properties in mice with acute lung injuries and regulated lipid metabolism …

Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A

H Lv, H Yang, Z Wang, H Feng, X Deng, G Cheng… - Cell death & …, 2019 - nature.com
Abstract Licochalcone A (Lico A), isolated from Xinjiang licorice Glycyrrhiza inflate, has been
shown to have antioxidative potential via the activation of nuclear factor-erythroid 2-related …

Redox activity of flavonoids: Impact on human health, therapeutics, and chemical safety

C Sarkar, P Chaudhary, S Jamaddar… - Chemical Research …, 2022 - ACS Publications
The cost-effectiveness of presently used therapies is a problem in overall redox-based
management, which is posing a significant financial burden on communities across the …

Current etiological comprehension and therapeutic targets of acetaminophen-induced hepatotoxicity

A Chowdhury, J Nabila, IA Temitope, S Wang - Pharmacological research, 2020 - Elsevier
Acetaminophen (APAP) is the most popular mild analgesic and antipyretic drug used
worldwide. APAP overdose leads to drug-induced hepatotoxicity and can cause hepatic …

Formononetin upregulates Nrf2/HO-1 signaling and prevents oxidative stress, inflammation, and kidney injury in methotrexate-induced rats

SH Aladaileh, OE Hussein, MH Abukhalil, SAM Saghir… - Antioxidants, 2019 - mdpi.com
Acute kidney injury (AKI) is a serious complication of methotrexate (MTX). This study
explored the protective effect of the isoflavone formononetin (FN) against MTX nephrotoxicity …

Fucoidan alleviates acetaminophen-induced hepatotoxicity via oxidative stress inhibition and Nrf2 translocation

Y Wang, J Wei, M Tu, J Gu, W Zhang - International Journal of Molecular …, 2018 - mdpi.com
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that leads to severe
hepatotoxicity at excessive doses. Fucoidan, a sulfated polysaccharide derived from brown …