Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics

F Gong, N Yang, X Wang, Q Zhao, Q Chen, Z Liu… - Nano Today, 2020 - Elsevier
The design and development of tumor microenvironment (TME)-responsive intelligent
nanoplatforms have attracted increasing interest to enhance the therapeutic effects of drugs …

Liposomal drug delivery systems and anticancer drugs

TOB Olusanya, RR Haj Ahmad, DM Ibegbu, JR Smith… - Molecules, 2018 - mdpi.com
Cancer is a life-threatening disease contributing to~ 3.4 million deaths worldwide. There are
various causes of cancer, such as smoking, being overweight or obese, intake of processed …

Enzyme responsive drug delivery systems in cancer treatment

M Shahriari, M Zahiri, K Abnous, SM Taghdisi… - Journal of Controlled …, 2019 - Elsevier
Recent technological approaches in drug delivery have attracted scientist interest for
improving therapeutic index of medicines and drug compliance. One of the powerful …

Stimuliresponsive nanotherapeutics for precision drug delivery and cancer therapy

Y Qiao, J Wan, L Zhou, W Ma, Y Yang… - Wiley …, 2019 - Wiley Online Library
Cancer remains one of the world's leading causes of death. However, most conventional
chemotherapeutic drugs only show a narrow therapeutic window in patients because of their …

Enzyme-responsive nanoparticles for drug release and diagnostics

R De La Rica, D Aili, MM Stevens - Advanced drug delivery reviews, 2012 - Elsevier
Enzymes are key components of the bionanotechnology toolbox that possess exceptional
biorecognition capabilities and outstanding catalytic properties. When combined with the …

Advanced strategies in liposomal cancer therapy: problems and prospects of active and tumor specific drug release

TL Andresen, SS Jensen, K Jørgensen - Progress in lipid research, 2005 - Elsevier
Tumor specific drug delivery has become increasingly interesting in cancer therapy, as the
use of chemotherapeutics is often limited due to severe side effects. Conventional drug …

Phospholipase A2 superfamily in cancer

Z Peng, Y Chang, J Fan, W Ji, C Su - Cancer Letters, 2021 - Elsevier
Phospholipase A2 enzymes (PLA 2 s) comprise a superfamily that is generally divided into
six subfamilies known as cytosolic PLA 2 s (cPLA 2 s), calcium-independent PLA 2 s (iPLA 2 …

Interfacing materials science and biology for drug carrier design

GK Such, Y Yan, APR Johnston… - Advanced …, 2015 - Wiley Online Library
Over the last ten years, there has been considerable research interest in the development of
polymeric carriers for biomedicine. Such delivery systems have the potential to significantly …

Enzyme-responsive liposomes for the delivery of anticancer drugs

F Fouladi, KJ Steffen, S Mallik - Bioconjugate Chemistry, 2017 - ACS Publications
Liposomes are nanocarriers that deliver the payloads at the target site, leading to
therapeutic drug concentrations at the diseased site and reduced toxic effects in healthy …

Receptors for a growing family of secreted phospholipases A2

G Lambeau, M Lazdunski - Trends in pharmacological sciences, 1999 - cell.com
Abstract Phospholipases A 2 (PLA 2 s) are enzymes that catalyse the hydrolysis of the sn-2
acyl bond of glycerophospholipids to produce free fatty acids and lysophospholipids …