Triggered activation and release of liposomal prodrugs and drugs in cancer tissue by secretory phospholipase A2

TL Andresen, SS Jensen, T Kaasgaard… - Current drug …, 2005 - ingentaconnect.com
The selectivity of anticancer drugs in targeting the tumour tissue presents a major problem in
cancer treatment. In this article we review a new generation of smart liposomal nanocarriers …

Leukotoxin diols from ground corncob bedding disrupt estrous cyclicity in rats and stimulate MCF-7 breast cancer cell proliferation

BM Markaverich, JR Crowley… - Environmental …, 2005 - ehp.niehs.nih.gov
Previous studies in our laboratory demonstrated that high-performance liquid
chromatography (HPLC) analysis of ground corncob bedding extracts characterized two …

Cyclooxygenase and lipoxygenase inhibitors in cancer therapy

G Ara, BA Teicher - Prostaglandins, leukotrienes and essential fatty acids, 1996 - Elsevier
Tumor growth, vascularization, invasion, and metastasis require activation and/or
proliferation of specific host cells, and, perhaps, deactivation and/or suppression of others …

Potential plasma lipid biomarkers in early-stage breast cancer

N Jiang, G Zhang, L Pan, C Yan, L Zhang, Y Weng… - Biotechnology …, 2017 - Springer
Objective To find new biomarkers for early diagnosis of breast cancer. Results 847 lipid
species were identified from 78 plasma samples (37 breast cancer samples and 41 healthy …

[HTML][HTML] Arachidonic acid attenuates cell proliferation, migration and viability by a mechanism independent on calcium entry

C Cantonero, J Sánchez-Collado, JJ Lopez… - International journal of …, 2020 - mdpi.com
Arachidonic acid (AA) is a phospholipase A2 metabolite that has been reported to mediate a
plethora of cellular mechanisms involved in healthy and pathological states such as platelet …

Discrimination between adenocarcinoma and normal pancreatic ductal fluid by proteomic and glycomic analysis

M Porterfield, P Zhao, H Han… - Journal of proteome …, 2014 - ACS Publications
Sensitive and specific biomarkers for pancreatic cancer are currently unavailable. The high
mortality associated with adenocarcinoma of the pancreatic epithelium justifies the broadest …

Plasma Levels of Phospholipase A2-IIA in Patients with Different Types of Malignancies: Prognosis and Association with Inflammatory and Coagulation Biomarkers

M Menschikowski, A Hagelgans, U Schuler… - Pathology & Oncology …, 2013 - Springer
It is well-known that the plasma level of group IIA phospholipase A 2 (sPLA 2-IIA) is
increased in patients with malignant diseases, but whether the up-regulated enzyme …

[HTML][HTML] Antitumoral effects of γCdcPLI, a PLA2 inhibitor from Crotalus durissus collilineatus via PI3K/Akt pathway on MDA-MB-231 breast cancer cell

SNC Gimenes, DS Lopes, PT Alves, FVPV Azevedo… - Scientific reports, 2017 - nature.com
Abstract Phospholipases A2 (PLA2s) overexpression is closely associated with the
malignant potential of breast cancers. Here, we showed for the first the antitumoral effects of …

[HTML][HTML] Metabolomic profiling of breast tumors using ductal fluid

L Matos Do Canto, C Marian… - International …, 2016 - spandidos-publications.com
Identification of new biomarkers for breast cancer remains critical in order to enhance early
detection of the disease and improve its prognosis. Towards this end, we performed an …

Group II phospholipase A2 in human male reproductive organs and genital tumors

M Kallajoki, KA Alanen, M Nevalainen… - The …, 1998 - Wiley Online Library
Abstract BACKGROUND Group II phospholipase A2 (PLA2) is a lipolytic enzyme suggested
to play a role in inflammation and antibacterial defence. In seminal fluid, the concentration of …