The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …

Translating genome-wide association study (GWAS) loci into causal variants and genes
requires accurate cell-type-specific enhancer–gene maps from disease-relevant tissues …

The success of precision oncology—which aims to match the right therapies to the right
patients based on molecular status—is predicated on a robust pipeline of molecular targets …

In human peripheral blood, circulating tumor DNA (ctDNA) is an excellent tumor biomarker
for noninvasive diagnosis, therapy and prognosis of cancer. Herein, an innovative enzyme …

In the decades following the discovery that genes encode proteins, scientists have tried to
exhaustively and comprehensively characterize the human genome. Recent advances in …

Lung cancer is a lethal malignancy lacking effective therapies. Emerging evidence suggests
that epigenetic enzyme mutations are closely related to the malignant phenotype of lung …

MicroRNAs (miRNAs) are small non-coding RNAs that posttranscriptionally regulate the
expression of most genes. They are involved in regulating many physiological processes …

Long noncoding RNAs (lncRNAs) possess the potential for therapeutic targeting to treat
many disorders, including cancers. Several RNA-based therapeutics (ASOs and small …

The toxic effects of chemotherapeutic drugs on normal tissues are still a major limiting factor
in cancer treatment. In this paper, a metal-organic framework (Zn-Co ZIF) loaded with liver …