Background Cancer is the most common cause of death and is still a serious public health
problem. Alkaloids, a class of bioactive compounds widely diffused in plants, especially …

Hepatocellular carcinoma (HCC) is due to poor prognosis and lack of availability of effective
treatment. Novel therapeutic strategies will be the fine tuning of intracellular ROS signaling …

This study aimed to develop a microemulsion formulation for topical delivery of Diacetyl
Boldine (DAB) and to evaluate its cytotoxicity against melanoma cell line (B16BL6) in vitro …

The alkaloid boldine occurs in the Chilean boldo tree (Peumus boldus). It acts as a free
radical scavenger and controls glycemia in diabetic rats. Various mechanisms have been …

Hepatocellular carcinoma (HCC), accounting for 85% of liver cancer cases, continues to be
the third leading cause of cancer-related deaths worldwide. Although various forms of …

Boldine is the main alkaloid of Peumus boldus Molina, widely used in the traditional
medicine for the treatment of digestive disorders. It is a compound with excellent antioxidant …

Drug‐induced liver injury (DILI) is a frequent cause responsible for acute liver failure (ALF).
Acetaminophen (APAP) is a known hepatotoxin predictably causing intrinsic DILI. At high …

Nanotechnology holds great promise for the development of treatments for deadly human
diseases, such as hepatocellular carcinoma (HCC). In the current study, we compared the …

Background Synthetic glucocorticoid therapeutic agent methylprednisolone (MPL), when
used for an extended period of time at high dose, promotes the development of reactive …

Peripheral nerve injury often results in poor functional recovery due to a prolonged period of
muscle denervation. In particular, absent axonal contact, denervated muscle can undergo …