The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging
across many parts of Africa. Resistance to existing drugs was emerging, and many programs …

African trypanosomes are bloodstream protozoan parasites that infect mammals including
humans, where they cause sleeping sickness. Long-lasting infection is required to favor …

Background In 2012 human African trypanosomiasis (HAT), also known as sleeping
sickness, was targeted for elimination as a public health problem, set to be achieved by …

Human African Trypanosomiasis (HAT, sleeping sickness) and Animal African
Trypanosomiasis (AAT) are neglected tropical diseases generally caused by the same …

With the incidence of sleeping sickness in decline and genuine progress being made
towards the WHO goal of eliminating sleeping sickness as a major public health concern …

The World Health Organisation (WHO) has placed twenty diseases into a group known as
neglected tropical diseases (NTDs), twelve of them being parasitic diseases: Chagas' …

The cysteine proteases, cruzain and Tbr CATL (rhodesain), are therapeutic targets for
Chagas disease and Human African Trypanosomiasis, respectively. Among the known …

The protozoan parasite Trypanosoma cruzi causes Chagas disease, an important public
health problem throughout Latin America. Current therapeutic options are characterised by …

Background The diagnosis of gambiense human African trypanosomiasis (gHAT) typically
involves 2 steps: a serological screen, followed by the detection of living trypanosome …

Diagnostics and drug delivery technologies engineered for low-resource settings aim to
meet their technical design specifications using strategies that are compatible with limited …