For years, it has been held that cathepsin D (CD) is involved in rather non-specific protein
degradation in a strongly acidic milieu of lysosomes. Studies with CD knock-out mice …

The neuronal ceroid lipofuscinoses (NCL) are severe neurodegenerative lysosomal storage
disorders of childhood, characterized by accumulation of autofluorescent ceroid …

Plasma, the soluble component of the human blood, is believed to harbor thousands of
distinct proteins, which originate from a variety of cells and tissues through either active …

The lysosomal aspartic protease cathepsin D (cath-D) is over-expressed and hyper-secreted
by epithelial breast cancer cells. This protease is an independent marker of poor prognosis …

In recent decades, dysregulation of proteases and atypical proteolysis have become
increasingly recognized as important hallmarks of cancer, driving community-wide efforts to …

Infusion of endothelial progenitor cells (EPC), but not of mature endothelial cells, promotes
neovascularization after ischemia. We performed gene expression profiling of EPC and …

Tumor cell invasion and metastasis are associated with the proteolytic activity of various
types of proteinases. Among them, cathepsins, which are lysosomal proteinases, have …

Blood vessels nourish organs with vital nutrients and oxygen and, thus, new vessels form
when the embryo needs to grow or wounds are to heal. However, forming new blood …

Abstract Cathepsin D (Cat D) is well known for its roles in metastasis, angiogenesis,
proliferation, and carcinogenesis in cancer. Despite Cat D being a promising target in …

Obesity, a pandemic disease, is caused by an excessive accumulation of fat that can have
detrimental effects on health. Adipose tissue plays a very important endocrine role, secreting …