Background The AD etiology is yet not properly known. Interactions among environmental
factors, multiple susceptibility genes and aging, contribute to AD. This study investigates the …

One of the major challenges for cancer therapeutics is the resistance of many tumor cells to
induction of cell death due to pro-survival signaling in the cancer cells. Here we review the …

Purpose: Ion channel activity is involved in several basic cellular behaviors that are integral
to metastasis (eg, proliferation, motility, secretion, and invasion), although their contribution …

Binding of activated forms of the proteinase inhibitor α 2-macroglobulin (α 2 M*) to cell
surface-associated GRP78 on 1-LN human prostate cancer cells causes their proliferation …

The extent of angiogenesis and/or vascular endothelial growth factor (VEGF) expression in
neuroblastoma tumors correlates with metastases, N-myc amplification, and poor clinical …

Two characteristics of highly malignant cells are their increased motility and secretion of
proteinases allowing these cells to penetrate surrounding basement membranes and …

Functional expression of voltage-gated sodium channel α-subunits (VGSCαs), specifically
Na v 1.7, is associated with strong metastatic potential in prostate cancer (CaP) in vitro …

Background: Brain-derived neutrophic factor (BDNF) is a member of the neutrophin family
that is known to activate the high-affinity tropomyosin-related receptor kinase B (TrkB). This …

Purpose: Given that nerve growth factor has previously been shown to be involved in breast
cancer progression, we have tested here the hypothesis that the other neurotrophins (NT) …

Non-metastatic glycoprotein melanoma protein B (GPNMB), also known as osteoactivin (OA)
is expressed in a wide array of tumors and represents an emerging target for drug …