[HTML][HTML] Unlocking the promise of mRNA therapeutics

E Rohner, R Yang, KS Foo, A Goedel… - Nature biotechnology, 2022 - nature.com
The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19)
has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical …

Extracellular vesicle analysis

A Hendrix, L Lippens, C Pinheiro, C Théry… - Nature Reviews …, 2023 - nature.com
Cells release small, phospholipid membrane-enclosed particles, collectively referred to as
extracellular vesicles (EVs), into their surroundings to enable intercellular communication …

Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications

J Mondal, S Pillarisetti, V Junnuthula, M Saha… - Journal of Controlled …, 2023 - Elsevier
Exosomes are endosome-derived nanovesicles involved in cellular communication. They
are natural nanocarriers secreted by various cells, making them suitable candidates for …

[HTML][HTML] Small extracellular vesicles isolation and separation: Current techniques, pending questions and clinical applications

Y Jia, L Yu, T Ma, W Xu, H Qian, Y Sun, H Shi - Theranostics, 2022 - ncbi.nlm.nih.gov
Extracellular vesicles, especially small extracellular vesicles (sEVs) are now accepted as
important messengers in cell-to-cell communication and as a promising drug delivery …

The cellular response to extracellular vesicles is dependent on their cell source and dose

DW Hagey, M Ojansivu, BR Bostancioglu, O Saher… - Science …, 2023 - science.org
Extracellular vesicles (EVs) have been established to play important roles in cell-cell
communication and shown promise as therapeutic agents. However, we still lack a basic …

[HTML][HTML] Extracellular vesicles: a rising star for therapeutics and drug delivery

S Du, Y Guan, A Xie, Z Yan, S Gao, W Li, L Rao… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the
same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural …

Tissue‐derived extracellular vesicles in cancers and non‐cancer diseases: present and future

SR Li, QW Man, X Gao, H Lin, J Wang… - Journal of …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are lipid‐bilayer membrane structures secreted by most cell
types. EVs act as messengers via the horizontal transfer of lipids, proteins, and nucleic …

Messenger RNA-based therapeutics and vaccines: what's beyond COVID-19?

D Li, C Liu, Y Li, R Tenchov, JM Sasso… - ACS pharmacology & …, 2023 - ACS Publications
With the rapid success in the development of mRNA vaccines against COVID-19 and with a
number of mRNA-based drugs ahead in the pipelines, mRNA has catapulted to the forefront …

[HTML][HTML] Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p/EFNA3/PI3K …

Y Zhuang, M Cheng, M Li, J Cui, J Huang, C Zhang… - Acta biomaterialia, 2022 - Elsevier
Angiogenesis is closely coupled with osteogenesis and has equal importance. Thus,
promoting angiogenesis during the bone repair process is vital for ideal bone regeneration …

[HTML][HTML] Engineered mesenchymal stem cell-derived extracellular vesicles: a state-of-the-art multifunctional weapon against Alzheimer's disease

T Yin, Y Liu, W Ji, J Zhuang, X Chen, B Gong, J Chu… - Theranostics, 2023 - ncbi.nlm.nih.gov
With the increase of population aging, the number of Alzheimer's disease (AD) patients is
also increasing. According to current estimates, approximately 11% of people over 65 suffer …