Colorectal cancer (CRC) is one the greatest contributors to cancer related mortality.
Although 5 year survival rate for patients at the early stage of CRC (stages I and II) is above …

The 90 kDa heat shock proteins (Hsp90), which are integrally involved in cell signaling,
proliferation, and survival, are ubiquitously expressed in cells. Many proteins in tumor cells …

Platinum compounds are a class of chemotherapy agents that posses a broad spectrum of
activity against several solid malignancies. Oxaliplatin (OXL) is a third-generation …

Platinum drugs are among the most active and widely used agents in the treatment of
different cancers. However, the great individual variability in both outcome and toxicity of …

Cisplatin is among the most important chemotherapeutic agents ever developed. It is a
critical component of therapeutic regimens in a broad range of malignancies. However …

Abstract The pyruvate mimetic 3-bromopyruvate (3-BP) is generally presented as an
inhibitor of glycolysis and has shown remarkable efficacy in not only preventing tumor …

Dithiocarbamates are a class of metal-chelating compounds with various applications in
medicine. They have been used for the treatment of bacterial and fungal infections, possible …

Background and Purpose Oxaliplatin is a platinum‐based chemotherapeutic drug used as a
first‐line therapy for colorectal cancer. However, its use is associated with severe …

Metastatic cancers commonly activate adaptive chemotherapy resistance, attributed to both
microenvironment‐dependent phenotypic plasticity and genetic characteristics of cancer …

Although platinum-based cancer chemotherapies produce painful peripheral neuropathy as
dose-limiting side effects, there are important differences in the pain syndromes produced by …