Role of prostaglandin E2 in macrophage polarization: Insights into atherosclerosis

W Wang, M Liang, L Wang, W Bei, X Rong, J Xu… - Biochemical …, 2023 - Elsevier
Atherosclerosis, a trigger of cardiovascular disease, poses grave threats to human health.
Although atherosclerosis depends on lipid accumulation and vascular wall inflammation …

The relevance of pathophysiological alterations in redox signaling of 4-hydroxynonenal for pharmacological therapies of major stress-associated diseases

M Jaganjac, L Milkovic, A Gegotek, M Cindric… - Free Radical Biology …, 2020 - Elsevier
Modern analytical methods combined with the modern concepts of redox signaling revealed
4-hydroxy-2-nonenal (4-HNE) as particular growth regulating factor involved in redox …

Inhibitors of NLRP3 inflammasome in ischemic heart disease: focus on functional and redox aspects

P Pagliaro, C Penna - Antioxidants, 2023 - mdpi.com
Myocardial ischemia-reperfusion injury (MIRI) is caused by several mechanisms, including
the production of reactive oxygen species (ROS), altered cellular osmolarity, and …

When nitrosative stress hits the endoplasmic reticulum: Possible implications in oxLDL/oxysterols-induced endothelial dysfunction

MG Nasoni, R Crinelli, L Iuliano, F Luchetti - Free Radical Biology and …, 2023 - Elsevier
Oxidized LDL (oxLDL) and oxysterols are known to play a crucial role in endothelial
dysfunction (ED) by inducing endoplasmic reticulum stress (ERS), inflammation, and …

The emerging role of COX-2, 15-LOX and PPARγ in metabolic diseases and cancer: an introduction to novel multi-target directed ligands (MTDLs)

RA Alaaeddine, PA Elzahhar, I AlZaim… - Current Medicinal …, 2021 - ingentaconnect.com
Emerging evidence supports an intertwining framework for the involvement of different
inflammatory pathways in a common pathological background for a number of disorders. Of …

Different approaches in therapy aiming to stabilize an unstable atherosclerotic plaque

M Kowara, A Cudnoch-Jedrzejewska - International Journal of Molecular …, 2021 - mdpi.com
Atherosclerotic plaque vulnerability is a vital clinical problem as vulnerable plaques tend to
rupture, which results in atherosclerosis complications—myocardial infarctions and …

Proeryptotic activity of 4-hydroxynonenal: A new potential physiopathological role for lipid peroxidation products

M Allegra, I Restivo, A Fucarino, A Pitruzzella, S Vasto… - Biomolecules, 2020 - mdpi.com
Background: Eryptosis is a physiological, apoptosis-like death of injured erythrocytes crucial
to prevent premature haemolysis and the pathological sequalae generated by cell-free …

Up-regulation of PCSK6 by lipid oxidation products: A possible role in atherosclerosis

G Testa, E Staurenghi, S Giannelli, B Sottero… - Biochimie, 2021 - Elsevier
Atherosclerosis is a degenerative disease characterized by lesions that develop in the wall
of large-and medium-sized arteries due to the accumulation of low-density lipoproteins …

Induction of cyclooxygenase-2 by overexpression of the human NADPH oxidase 5 (NOX5) gene in aortic endothelial cells

J Marqués, A Cortés, Á Pejenaute, E Ansorena… - Cells, 2020 - mdpi.com
Oxidative stress is a main molecular mechanism that underlies cardiovascular diseases. A
close relationship between reactive oxygen species (ROS) derived from NADPH oxidase …

27‐hydroxycholesterol promotes oligodendrocyte maturation: implications for hypercholesterolemia‐associated brain white matter changes

V Alanko, A Gaminde‐Blasco, T Quintela‐López… - Glia, 2023 - Wiley Online Library
Abstract Oxidized cholesterol metabolite 27‐hydroxycholesterol (27‐OH) is a potential link
between hypercholesterolemia and neurodegenerative diseases since unlike peripheral …