The pathophysiology of heart failure (HF) is characterized by hemodynamic abnormalities
that result in neurohormonal activation and autonomic imbalance with increase in …

A great deal of experimental evidence suggests that ligands can stabilize different receptor
active states that go on to interact with cellular signaling proteins to form a range of different …

β-arrestin1 (or arrestin2) and β-arrestin2 (or arrestin3) are ubiquitously expressed cytosolic
adaptor proteins that were originally discovered for their inhibitory role in G protein–coupled …

The patient is a 63-year-old man with a history of wellcontrolled hypertension who is
diagnosed with diffuse large B-cell lymphoma and treated with a doxorubicincontaining …

G protein-coupled receptors (GPCRs) remain a major domain of pharmaceutical discovery.
The identification of GPCR lead compounds and their optimization are now structure-based …

Beta-blockers are widely used molecules that are able to antagonize β-adrenergic receptors
(ARs), which belong to the G protein-coupled receptor family and receive their stimulus from …

Analgesic design and evaluation have been driven by the desire to create high-affinity high-
selectivity mu (μ)-opioid peptide (MOP) receptor agonists. Such ligands are the mainstay of …

Significance: Antineoplastic therapies have significantly improved the prognosis of oncology
patients. However, these treatments can bring to a higher incidence of side-effects, including …

The two branches of the autonomic nervous system (ANS), adrenergic and cholinergic, exert
a multitude of effects on the human myocardium thanks to the activation of distinct G protein …

Background To maintain the balance between the demand of the body and supply (cardiac
output), cardiac performance is tightly regulated via the parasympathetic and sympathetic …