β-adrenergic receptors (βARs) are critical regulators of acute cardiovascular physiology. In
response to elevated catecholamine stimulation during development of congestive heart …

The β-adrenergic receptors (βARs) include three subtypes, β 1, β 2 and β 3. These receptors
are widely expressed and regulate numerous physiological processes including …

The β 2-adrenergic receptor (β 2 AR) is a prototypical G protein-coupled receptor that
mediates many hormonal responses, including cardiovascular and pulmonary function. β …

Anticancer drugs play an important role in reducing mortality rates and increasing life
expectancy in cancer patients. Treatments include monotherapy and/or a combination of …

Human G protein-coupled receptors (GPCRs), especially adrenoceptors, play a crucial role
in maintaining important physiological activities including cardiovascular and pulmonary …

Biased signalling is a natural result of GPCR allosteric function and should be expected from
any and all synthetic and natural agonists. Therefore, it may be encountered in all agonist …

Diabetes mellitus (DM) is an independent risk factor for heart disease and its underlying
mechanisms are unclear. Increased expression of diabetic marker miR-29 family miRNAs …

The stress-related catecholamine hormones and the α-and β-adrenergic receptors (α-and β-
AR) may affect carcinogenesis. The β-AR GRK/β-arrestin biased agonist carvedilol can …

Background: Evolution in computer engineering, availability of increasing amounts of data
and the development of new and fast docking algorithms and software have led to improved …

Pain management is the specialized medical practice of modulating pain perception and
thus easing the suffering and improving the life quality of individuals suffering from painful …