Endoplasmic reticulum (ER) is a dynamic organelle that participates in a number of cellular
functions by controlling lipid metabolism, calcium stores, and proteostasis. Under stressful …

Highly sophisticated mechanisms that modulate protein structure and function, which involve
synthesis and degradation, have evolved to maintain cellular homeostasis. Perturbations in …

Plasma cell differentiation requires silencing of B cell transcription, while it establishes
antibody-secretory function and long-term survival. The transcription factors Blimp-1 and …

Disturbances in protein folding and membrane compositions in the endoplasmic reticulum
(ER) elicit the unfolded protein response (UPR). Each of three UPR sensory proteins …

Adrenocortical carcinoma (ACC) is a rare malignancy that harbors a dismal prognosis in
advanced stages. Mitotane is approved as an orphan drug for treatment of ACC and …

CFTR biogenesis starts with its co-translational insertion into the membrane of endoplasmic
reticulum and folding of the cytosolic domains, towards the acquisition of a fully folded …

Under physiological and pathological conditions, cells activate the unfolded protein
response (UPR) to deal with the accumulation of unfolded or misfolded proteins in the …

Obese subjects exhibit lower adipose tissue oxygen consumption in accordance with the
lower adipose tissue blood flow. Thus, compared with lean subjects, obese subjects have …

The APOE gene is one of currently only two genes that have consistently been associated
with longevity. Apolipoprotein E (APOE) is a plasma protein which plays an important role in …

Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms
in response to stress. One of the best-characterized pathways, the UPR (unfolded protein …