Exploring the role of neuropeptides in depression and anxiety

T Rana, T Behl, A Sehgal, S Singh, N Sharma… - Progress in Neuro …, 2022 - Elsevier
Depression is one of the most prevalent forms of mental disorders and is the most common
cause of disability in the Western world. Besides, the harmful effects of stress-related mood …

Role of neuropeptides in anxiety, stress, and depression: from animals to humans

V Kormos, B Gaszner - Neuropeptides, 2013 - Elsevier
Major depression, with its strikingly high prevalence, is the most common cause of disability
in communities of Western type, according to data of the World Health Organization. Stress …

Glucocorticoid-driven NLRP3 inflammasome activation in hippocampal microglia mediates chronic stress-induced depressive-like behaviors

X Feng, Y Zhao, T Yang, M Song, C Wang… - Frontiers in molecular …, 2019 - frontiersin.org
Chronic stress is a key risk factor for depression, and microglia have been implicated in the
pathogenesis of the disease. Recent studies show that the Nod-like receptor protein 3 …

Unpredictable chronic mild stress not chronic restraint stress induces depressive behaviours in mice

S Zhu, R Shi, J Wang, JF Wang, XM Li - Neuroreport, 2014 - journals.lww.com
The chronic stress model was developed on the basis of the stress–diathesis hypothesis of
depression. However, these behavioural responses associated with different stress …

Stress and opioids: role of opioids in modulating stress-related behavior and effect of stress on morphine conditioned place preference

A Bali, PK Randhawa, AS Jaggi - Neuroscience & Biobehavioral Reviews, 2015 - Elsevier
Research studies have defined the important role of endogenous opioids in modulating
stress-associated behavior. The release of β-endorphins in the amygdala in response to …

[HTML][HTML] Role of stress in skin diseases: a neuroendocrine-immune interaction view

H Zhang, M Wang, X Zhao, Y Wang, X Chen… - Brain, Behavior, and …, 2023 - Elsevier
Psychological stress is a crucial factor in the development of many skin diseases, and the
stigma caused by skin disorders may further increase the psychological burden, forming a …

Depression as a neuroendocrine disorder: emerging neuropsychopharmacological approaches beyond monoamines

M Chávez-Castillo, V Núñez, M Nava… - Advances in …, 2019 - Wiley Online Library
Depression is currently recognized as a crucial problem in everyday clinical practice, in light
of ever‐increasing rates of prevalence, as well as disability, morbidity, and mortality related …

Are neuropeptides relevant for the mechanism of action of SSRIs?

M Gołyszny, E Obuchowicz - Neuropeptides, 2019 - Elsevier
Selective serotonin reuptake inhibitors (SSRIs) are drugs of first choice in the therapy of
moderate to severe depression and anxiety disorders. Their primary mechanism of action is …

[HTML][HTML] Noradrenergic modulation of stress resilience

X Zhai, D Zhou, Y Han, MH Han, H Zhang - Pharmacological Research, 2023 - Elsevier
Resilience represents an active adaption process in the face of adversity, trauma, tragedy,
threats, or significant sources of stress. Investigations of neurobiological mechanisms of …

Galanin promotes autophagy and alleviates apoptosis in the hypertrophied heart through FoxO1 pathway

I Martinelli, A Timotin, P Moreno-Corchado, D Marsal… - Redox biology, 2021 - Elsevier
Autophagy and apoptosis are powerful regulators of multiple facets of cellular metabolism
and homeostasis. Here, we uncover that galanin, a pleiotropic peptide, regulates cardiac …