The antiretroviral treatment (ART) developed to control HIV infection led to a revolution in the
prognosis of people living with HIV (PLWH). PLWH underwent from suffering severe disease …

Simple Summary CD38 remains an interesting target for anticancer therapy. Its relatively
high abundance in neoplasms and crucial impact on NAD+/cADPR metabolism and the …

While numerous cellular proteins in the HIV envelope are known to alter virus infection,
methodology to rapidly phenotype the virion surface in a high throughput, single virion …

CD38 is highly expressed on multiple myeloma (MM) cells and plays a role in regulating
tumor generation and development. CD38 monoclonal antibodies (mAbs) have been used …

The ability of virally suppressive antiretroviral therapy use to extend the life span of people
with HIV (PWH) implies that the age of PWH will also increase. Among PWH, extended …

Introduction Immunological non-responders (INR) are people living with HIV (PLHIV) who
fail to fully restore CD4+ T-cell counts despite complete viral suppression with antiretroviral …

Background Chronic immune activation plays a significant role in the pathogenesis and
disease progression of human immunodeficiency virus (HIV), and the existing interventions …

Despite abundant evidence correlating T cell CD38 expression and HIV infection
pathogenesis, its role as a CD4T cell immunometabolic regulator remains unclear. We find …

CD38 is a multifunctional molecule that functions both as a transmembrane signaling
receptor and as an ectoenzyme with important roles in cell adhesion, calcium regulation and …

Background: Age-associated comorbidities are higher in people with HIV (PWH) than HIV-
negative individuals. This is partially attributed to immune activation and CD38 expression …