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Opioid treatment of pain is generally safe with 0.5% or less events from respiratory
depression. However, fatalities are regularly reported. The only treatment currently available …

Background: Postoperative opioid-induced respiratory depression (RD) is a significant
cause of death and brain damage in the perioperative period. The authors examined …

BACKGROUND: The incidence, severity, and duration of postoperative oxygen desaturation
in the general surgical population are poorly characterized. We therefore used continuous …

Objectives The primary study objective was to investigate the impact of surveillance
monitoring (ie, continuous monitoring optimized for deterioration detection) on mortality and …

Urinary retention is common after anesthesia and surgery, reported incidence of between
5% and 70%. Comorbidities, type of surgery, and type of anesthesia influence the …

BACKGROUND: Opioid-related adverse events are a serious problem in hospitalized
patients. Little is known about patients who are likely to experience opioid-induced …

Opioid-induced respiratory depression is potentially life-threatening and often regarded as
the main hazard of opioid use. Main cause of death is cardiorespiratory arrest with hypoxia …

Respiratory depression limits the use of opioid analgesia. Although well described clinically,
the specific mechanisms of opioid action on respiratory control centres in the brain have …

Opioid use has risen dramatically in the past three decades. In the USA, opioid overdose
has become a leading cause of unintentional death, surpassing motor vehicle accidents. A …