Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and
represents a high-grade neoplasm of skeletal myoblast-like cells. Decades of clinical and …

Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes …

Objective To compare tumor risk in the 4 Beckwith-Wiedemann syndrome (BWS) molecular
subgroups: Imprinting Control Region 1 Gain of Methylation (ICR1-GoM), Imprinting Control …

Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the
unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic …

Pediatricians have relied on methods for determining skeletal maturation for> 75 years.
Bone age continues to be a valuable tool in assessing children's health. New technology for …

An association between assisted reproduction technologies (ART) and abnormal genomic
imprinting in humans has been recognized for several years; however, the magnitude of this …

Abnormally excessive growth results from perturbation of a complex interplay of genetic,
epigenetic, and hormonal factors that orchestrate human growth. Overgrowth syndromes …

Renal malignancies are among the most prevalent pediatric cancers. The most common is
favorable histology Wilms tumor (FHWT), which has 5‐year overall survival exceeding 90 …

Beckwith–Wiedemann syndrome (BWS) is characterized by cancer predisposition,
overgrowth and highly variable association of macroglossia, abdominal wall defects …

Beckwith-Wiedemann syndrome (BWS) is a human loss-of-imprinting syndrome primarily
characterized by macrosomia, macroglossia, and abdominal wall defects. BWS has been …