Fibrosis and alcohol-related liver disease

C Lackner, D Tiniakos - Journal of hepatology, 2019 - Elsevier
Histological fibrosis stage is one of the most important prognostic factors in compensated
and decompensated alcohol-related liver disease (ALD). Morphological assessment of …

[HTML][HTML] VDAC1 at the intersection of cell metabolism, apoptosis, and diseases

V Shoshan-Barmatz, A Shteinfer-Kuzmine, A Verma - Biomolecules, 2020 - mdpi.com
The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …

Quercetin Protects Ethanol‐Induced Hepatocyte Pyroptosis via Scavenging Mitochondrial ROS and Promoting PGC‐1α‐Regulated Mitochondrial Homeostasis in L02 …

X Zhao, C Wang, S Dai, Y Liu, F Zhang… - Oxidative medicine …, 2022 - Wiley Online Library
Alcoholic liver disease (ALD) is a multifaceted process that involves excessive lipid, reactive
oxygen species (ROS) production, unbalanced mitochondrial homeostasis, and ultimate cell …

Mitochondrial dysfunction and liver disease: role, relevance, and potential for therapeutic modulation

P Middleton, N Vergis - Therapeutic Advances in …, 2021 - journals.sagepub.com
Mitochondria are key organelles involved in energy production as well as numerous
metabolic processes. There is a growing interest in the role of mitochondrial dysfunction in …

Mitochondrial depolarization after acute ethanol treatment drives mitophagy in living mice

DJ Samuvel, L Li, Y Krishnasamy, M Gooz… - Autophagy, 2022 - Taylor & Francis
Ethanol increases hepatic mitophagy driven by unknown mechanisms. Type 1 mitophagy
sequesters polarized mitochondria for nutrient recovery and cytoplasmic remodeling. In …

Protective effects of fucoidan against ethanol-induced liver injury through maintaining mitochondrial function and mitophagy balance in rats

H Zhao, S Liu, H Zhao, Y Liu, M Xue, H Zhang, X Qiu… - Food & Function, 2021 - pubs.rsc.org
For alcoholic liver disease (ALD), mitophagy has been reported as a promising therapeutic
strategy to alleviate the hepatic lesion elicited by ethanol. This study was conducted to …

Dihydromyricetin improves mitochondrial outcomes in the liver of alcohol-fed mice via the AMPK/Sirt-1/PGC-1α signaling axis

J Silva, MH Spatz, C Folk, A Chang, E Cadenas… - Alcohol, 2021 - Elsevier
Alcoholic liver disease (ALD), due to the multifactorial damage associated with alcohol
(ethanol) consumption and metabolism, is one of the most prevalent liver diseases in the …

Insights of mitochondrial involvement in alcoholic fatty liver disease

N Subramaiyam - Journal of Cellular Physiology, 2023 - Wiley Online Library
Alcoholic liver disease (ALD) is a global concern affecting most of the population and
leading to the development of end‐stage liver disease. Metabolic alterations due to …

[HTML][HTML] Advancements in the alcohol-associated liver disease model

L Zhu, HD Li, JJ Xu, JJ Li, M Cheng, XM Meng… - Biomolecules, 2022 - mdpi.com
Alcohol-associated liver disease (ALD) is an intricate disease that results in a broad
spectrum of liver damage. The presentation of ALD can include simple steatosis …

[HTML][HTML] The mechanism of dysbiosis in alcoholic liver disease leading to liver cancer

N Méndez-Sánchez, A Valencia-Rodríguez… - Hepatoma …, 2020 - ncbi.nlm.nih.gov
Currently, alcoholic liver disease (ALD) is one of the most prevalent chronic liver diseases
worldwide, representing one of the main etiologies of cirrhosis and hepatocellular …