Skeletal muscle atrophy is a well-known consequence of spaceflight. Because of the
potential significant impact of muscle atrophy and muscle dysfunction on astronauts and …

Humans and other mammalian species possess an endogenous circadian clock system that
has evolved in adaptation to periodically reoccurring environmental changes and drives …

Human Space exploration has created new challenges and new opportunities for science.
Reaching beyond the Earth's surface has raised the issue of the importance of gravity for the …

Background If interplanetary travel is to be successful over the coming decades, it is
essential that countermeasures to minimize deterioration of the musculoskeletal system are …

Background The muscle decline due to aging, called sarcopenia and functional
compromise, are common occurrences in patients with chronic heart failure (CHF). Intestinal …

Sarcopenia has a significant negative impact on healthspan in the elderly and effective
pharmacologic interventions remain elusive. We have previously demonstrated that …

Physical inactivity represents a heavy burden for modern societies and is spreading
worldwide, it is a recognised pandemic and is the fourth cause of global mortality. Not …

Gravity-dependent physical processes strongly affect the ability of elderly people to maintain
musculoskeletal health by reducing muscle atrophy and increasing bone mineral density …

Recent advancements in next generation spacecrafts have reignited public excitement over
life beyond Earth. However, to safeguard the health and safety of humans in the hostile …

Novel treatments for muscle wasting are of significant value to patients with disease states
that result in muscle weakness, injury recovery after immobilization and bed rest, and for …