Down syndrome is the most common genetic developmental disorder in humans and is
caused by partial or complete triplication of human chromosome 21 (trisomy 21). It is a …

BACKGROUND: Recent advances in medical care have increased life expectancy and
improved the quality of life for people with Down syndrome (DS). These advances are the …

Neurodevelopmental impairment is a common and important long-term morbidity among
infants with congenital heart disease (CHD). More than half of those with complex CHD will …

Background Down syndrome (DS) is associated with variable intellectual disability and
multiple health and psychiatric comorbidities. The impact of such comorbidities on cognitive …

Objective To investigate motor and cognitive developmental profiles and to evaluate the
correlation between two developmental areas and assess the influencing factors of the …

Abstract Background Even though Down syndrome is the most common chromosomal
cause of intellectual disability, studies on early development are scarce. Aim To describe …

Congenital heart disease (CHD) is present in approximately 50% of patients with trisomy 21
(T21) and Turner syndrome (TS). According to the American Academy of Pediatrics, every …

Although many risk factors in CHD are not modifiable, there is promise for interventions to
improve neurodevelopmental outcomes in patients with CHD. Biomarkers are needed to …

Background Specific medical conditions are more prevalent in Down syndrome (DS)
compared to the general population. Medical heterogeneity has also been hypothesized to …

Background Individuals with Down syndrome are predisposed to a number of chronic health
conditions, but the relationship between these conditions and cognitive ability is not clear …