Nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions worldwide.
NAFLD and type 2 diabetes mellitus (T2DM) are known to frequently coexist and act …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …

Ceramides contribute to the lipotoxicity that underlies diabetes, hepatic steatosis, and heart
disease. By genetically engineering mice, we deleted the enzyme dihydroceramide …

Proper regulation and management of energy, substrate diversity and quantity, as well as
macromolecular synthesis and breakdown processes, are fundamental to cellular and …

Metabolism research has made tremendous progress over the last several decades in
establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and …

Obesity is a major health risk factor, and obesity-induced morbidity and complications
account for huge costs for affected individuals, families, healthcare systems, and society at …

Low-grade tissue inflammation induced by obesity can result in insulin resistance, which in
turn is a key cause of type 2 diabetes mellitus. Cells of the innate immune system produce …

In obesity and dyslipidemia, the oversupply of fat to tissues not suited for lipid storage
induces cellular dysfunction that underlies diabetes and cardiovascular disease (ie …

Nonalcoholic fatty liver disease (NAFLD) is a major worldwide health problem. Recent
studies suggest that the gut microbiota influences NAFLD pathogenesis. Here, a murine …