Regulation, functions and transmission of bivalent chromatin during mammalian development
TA Macrae, J Fothergill-Robinson… - … reviews Molecular cell …, 2023 - nature.com
Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …
landscape that mediates gene expression programmes. During development, mammalian …
Dynamics of the epigenetic landscape during the maternal-to-zygotic transition
MA Eckersley-Maslin, C Alda-Catalinas… - … Reviews Molecular Cell …, 2018 - nature.com
A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition
Maternal-to-zygotic transition (MZT) is essential for the formation of a new individual, but is
still poorly understood despite recent progress in analysis of gene expression and DNA …
still poorly understood despite recent progress in analysis of gene expression and DNA …
Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development
Abstract H3K9me3-dependent heterochromatin is a major barrier of cell fate changes that
must be reprogrammed after fertilization. However, the molecular details of these events are …
must be reprogrammed after fertilization. However, the molecular details of these events are …
Insights into epigenetic patterns in mammalian early embryos
R Xu, C Li, X Liu, S Gao - Protein & cell, 2021 - academic.oup.com
Mammalian fertilization begins with the fusion of two specialized gametes, followed by major
epigenetic remodeling leading to the formation of a totipotent embryo. During the …
epigenetic remodeling leading to the formation of a totipotent embryo. During the …
DNA methylation: roles in mammalian development
ZD Smith, A Meissner - Nature Reviews Genetics, 2013 - nature.com
DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …
mammalian development. Although the methylation status of most CpG dinucleotides in the …
[HTML][HTML] Sex and gender differences in developmental programming of metabolism
Background The early life environment experienced by an individual in utero and during the
neonatal period is a major factor in shaping later life disease risk-including susceptibility to …
neonatal period is a major factor in shaping later life disease risk-including susceptibility to …
Role of H3K9me3 heterochromatin in cell identity establishment and maintenance
Compacted, transcriptionally repressed chromatin, referred to as heterochromatin,
represents a major fraction of the higher eukaryotic genome and exerts pivotal functions of …
represents a major fraction of the higher eukaryotic genome and exerts pivotal functions of …
DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos
DM Messerschmidt, BB Knowles… - Genes & …, 2014 - genesdev.cshlp.org
Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …
embryonic development, cells are directed toward their future lineages, and DNA …
Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health
BACKGROUND A defining feature of sexual reproduction is the transmission of genomic
information from both parents to the offspring. There is now compelling evidence that the …
information from both parents to the offspring. There is now compelling evidence that the …