[HTML][HTML] A single-cell time-lapse of mouse prenatal development from gastrula to birth
The house mouse (Mus musculus) is an exceptional model system, combining genetic
tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …
tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …
[HTML][HTML] Embryo-scale reverse genetics at single-cell resolution
The maturation of single-cell transcriptomic technologies has facilitated the generation of
comprehensive cellular atlases from whole embryos,,–. A majority of these data, however …
comprehensive cellular atlases from whole embryos,,–. A majority of these data, however …
STIGMA: Single-cell tissue-specific gene prioritization using machine learning
S Balachandran, CA Prada-Medina, MA Mensah… - The American Journal of …, 2024 - cell.com
Clinical exome and genome sequencing have revolutionized the understanding of human
disease genetics. Yet many genes remain functionally uncharacterized, complicating the …
disease genetics. Yet many genes remain functionally uncharacterized, complicating the …
Shared features in ear and kidney development–implications for oto-renal syndromes
SX Wang, A Streit - Disease Models & Mechanisms, 2024 - journals.biologists.com
The association between ear and kidney anomalies has long been recognized. However,
little is known about the underlying mechanisms. In the last two decades, embryonic …
little is known about the underlying mechanisms. In the last two decades, embryonic …
Heterozygous loss-of-function variants in DOCK4 cause neurodevelopmental delay and microcephaly
C Herbst, V Bothe, M Wegler, S Axer-Schaefer… - Human genetics, 2024 - Springer
Neurons form the basic anatomical and functional structure of the nervous system, and
defects in neuronal differentiation or formation of neurites are associated with various …
defects in neuronal differentiation or formation of neurites are associated with various …